About: Cytogenetics and cytology of retinoblastomas

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using the repeated FISH technique, the average distances between the nuclear membrane and the fluorescence gravity centre (FGC) of seven selected chromosomes were determined in the same tumour population and three other cell types. Chromosome order in positioning from the nuclear membrane was similar in all cell populations investigated. Our experimental studies were focused on specific genetic loci relevant for retinoblastoma tumour pathogenesis. We revealed a certain heterogeneity in the copy number of the Rb1, N-myc and TP53 gene loci in tumour cells. In addition, in lymphocytes isolated from peripheral blood of the patients, a high degree of copy number heterogeneity was also detected. In 60 % of analysed retinoblastomas we observed numerical aberration involving the centromeric region of chromosome 6. In these tumours, apoptotic bodies were found irrespective of clinical therapy. Using the repeated FISH technique, the average distances between the nuclear membrane and the fluorescence gravity centre (FGC) of seven selected chromosomes were determined in the same tumour population and three other cell types. Chromosome order in positioning from the nuclear membrane was similar in all cell populations investigated. Our experimental studies were focused on specific genetic loci relevant for retinoblastoma tumour pathogenesis. We revealed a certain heterogeneity in the copy number of the Rb1, N-myc and TP53 gene loci in tumour cells. In addition, in lymphocytes isolated from peripheral blood of the patients, a high degree of copy number heterogeneity was also detected. In 60 % of analysed retinoblastomas we observed numerical aberration involving the centromeric region of chromosome 6. In these tumours, apoptotic bodies were found irrespective of clinical therapy. (en)
Title	Cytogenetics and cytology of retinoblastomas Cytogenetics and cytology of retinoblastomas (en)
skos:prefLabel	Cytogenetics and cytology of retinoblastomas Cytogenetics and cytology of retinoblastomas (en)
skos:notation	RIV/00216224:14330/03:00008142!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/01/0186), P(IAA5004306), P(IAB5004102), P(IBS5004010), P(NC6987), Z(AV0Z5004920), Z(MSM 143300002)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Taslerová, Renata Kozubek, Michal Gajdušková, Pavla Gajová, Hana Bártová, Eva Kozubek, Stanislav Krontorád Koutná, Irena Žlůvová, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	602570
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/03:00008142
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retinoblastoma; Numerical aberrations; Nuclear topography; Apoptosis (en)
http://linked.open.../riv/klicoveSlovo	retinoblastoma Nuclear topography Numerical aberrations Apoptosis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[F6757041B137]
http://linked.open...i/riv/nazevZdroje	J Cancer Res. Clin.Oncol.
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques Epigenetic control of gene expression in malignant diseases Human genome structure Nuclear topology of some protooncogenes in human neutrophilic granulocytes and leukemic cells Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	129
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Kozubek, Michal Krontorád Koutná, Irena Žlůvová, Jitka Gajdušková, Pavla Taslerová, Renata Gajová, Hana
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
issn	0171-5216
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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