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  • The spatial arrangement of some genetic elements relative to chromosome territories and in parallel with the cell nucleus was investigated in human lymphocytes. The structure of the chromosome territories was studied in chromosomes containing regions (clusters) of highly expressed genes (HSA 9, 17) and those without such clusters (HSA 8, 13). In chromosomes containing highly expressed regions, the elements pertaining to these regions were found close to the centre of the nucleus on the inner sides of chromosome territories; those pertaining to regions with low expression were localized close to the nuclear membrane on the opposite sides of the territories. In chromosomes with generally low expression (HSA 8, 13), the elements investigated were found symmetrically distributed over the territories.
  • The spatial arrangement of some genetic elements relative to chromosome territories and in parallel with the cell nucleus was investigated in human lymphocytes. The structure of the chromosome territories was studied in chromosomes containing regions (clusters) of highly expressed genes (HSA 9, 17) and those without such clusters (HSA 8, 13). In chromosomes containing highly expressed regions, the elements pertaining to these regions were found close to the centre of the nucleus on the inner sides of chromosome territories; those pertaining to regions with low expression were localized close to the nuclear membrane on the opposite sides of the territories. In chromosomes with generally low expression (HSA 8, 13), the elements investigated were found symmetrically distributed over the territories. (en)
Title
  • The 3D structure of human chromosomes in cell nuclei
  • The 3D structure of human chromosomes in cell nuclei (en)
skos:prefLabel
  • The 3D structure of human chromosomes in cell nuclei
  • The 3D structure of human chromosomes in cell nuclei (en)
skos:notation
  • RIV/00216224:14330/02:00006557!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA202/01/0197), P(GA301/01/0186), P(IAA1065203), P(IBS5004010), P(NC5955), Z(AV0Z5004920), Z(MSM 143300002)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 671950
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14330/02:00006557
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • chromosome structure; confocal microscopy; mathematical models; nuclear architecture (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [B2312DE92203]
http://linked.open...i/riv/nazevZdroje
  • Chromosome Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 10
http://linked.open...iv/tvurceVysledku
  • Kozubek, Stanislav
  • Lukášová, Emilie
  • Falk, Martin
  • Kozubek, Michal
  • Amrichová, Jana
http://linked.open...n/vavai/riv/zamer
issn
  • 0967-3849
number of pages
http://localhost/t...ganizacniJednotka
  • 14330
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