About: Nuclear structure and gene activity in human differentiated cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The nuclear arrangement of the ABL, c-MYC, and RB1 genes was quantitatively investigated in human undifferentiated HL-60 cells and in a terminally differentiated population of human granulocytes. The ABL gene was expressed in both cell types, the c-MYC gene was active in HL-60 cells and down-regulated in granulocytes, and expression of the RB1 gene was undetectable in HL-60 cells but up-regulated in granulocytes. The distances of these genes to the nuclear center (membrane), to the center of the corresponding chromosome territory, and to the nearest centromere were determined. During granulopoesis, the majority of selected genetic structures were repositioned closer to the nuclear periphery. The nuclear reposition of the genes studied did not correlate with the changes of their expression. In both cell types, the c-MYC and RB1 genes were located at the periphery of the chromosome territories regardless of their activity. The nuclear arrangement of the ABL, c-MYC, and RB1 genes was quantitatively investigated in human undifferentiated HL-60 cells and in a terminally differentiated population of human granulocytes. The ABL gene was expressed in both cell types, the c-MYC gene was active in HL-60 cells and down-regulated in granulocytes, and expression of the RB1 gene was undetectable in HL-60 cells but up-regulated in granulocytes. The distances of these genes to the nuclear center (membrane), to the center of the corresponding chromosome territory, and to the nearest centromere were determined. During granulopoesis, the majority of selected genetic structures were repositioned closer to the nuclear periphery. The nuclear reposition of the genes studied did not correlate with the changes of their expression. In both cell types, the c-MYC and RB1 genes were located at the periphery of the chromosome territories regardless of their activity. (en)
Title	Nuclear structure and gene activity in human differentiated cells Nuclear structure and gene activity in human differentiated cells (en)
skos:prefLabel	Nuclear structure and gene activity in human differentiated cells Nuclear structure and gene activity in human differentiated cells (en)
skos:notation	RIV/00216224:14330/02:00006555!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/01/0186), P(IAB5004102), P(IBS5004010), Z(AV0Z5004920), Z(MSM 143300002)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubek, Michal Hausmann, Michael Gajdušková, Pavla Cafourková, Alena Gajová, Hana Bártová, Eva Kozubek, Stanislav Krontorád Koutná, Irena Lukášová, Emilie Skalníková, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	656128
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/02:00006555
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human genome structure; interphase cell nuclei (en)
http://linked.open.../riv/klicoveSlovo	human genome structure interphase cell nuclei
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9218EEC9191D]
http://linked.open...i/riv/nazevZdroje	Journal of Structural Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques Nuclear topology of some protooncogenes in human neutrophilic granulocytes and leukemic cells Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	139
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Lukášová, Emilie Kozubek, Michal Hausmann, Michael Krontorád Koutná, Irena Gajdušková, Pavla Skalníková, Magdalena Gaňová, Alena Gajová, Hana
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
issn	1047-8477
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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