About: 3D Structure of the human genome: Order in randomness

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A complex study of the spatial arrangement of different genetic elements (genes, centromeres and chromosomal domains) in the cell nucleus is presented and the principles of this arrangement are discussed. We show that the radial location of genetic elements in the three-dimensional (3D) space between the center of the nucleus and the nuclear membrane is element specific and dependent on the position of the element on the chromosome. In contrast, mutual angular positioning of both homologous and heterologous genetic elements is, in the majority of cases, random. In several cases, tethering of heterologous genetic elements was observed. This close proximity of specific loci may be responsible for their mutual rearrangement and the development of cancer. Comparison of our results with transcriptome maps shows that the nuclear location of chromosomal domains with highly expressed genes is more central when compared with chromosomes with low expression. A complex study of the spatial arrangement of different genetic elements (genes, centromeres and chromosomal domains) in the cell nucleus is presented and the principles of this arrangement are discussed. We show that the radial location of genetic elements in the three-dimensional (3D) space between the center of the nucleus and the nuclear membrane is element specific and dependent on the position of the element on the chromosome. In contrast, mutual angular positioning of both homologous and heterologous genetic elements is, in the majority of cases, random. In several cases, tethering of heterologous genetic elements was observed. This close proximity of specific loci may be responsible for their mutual rearrangement and the development of cancer. Comparison of our results with transcriptome maps shows that the nuclear location of chromosomal domains with highly expressed genes is more central when compared with chromosomes with low expression. (en)
Title	3D Structure of the human genome: Order in randomness 3D Structure of the human genome: Order in randomness (en)
skos:prefLabel	3D Structure of the human genome: Order in randomness 3D Structure of the human genome: Order in randomness (en)
skos:notation	RIV/00216224:14330/02:00006554!RIV11-AV0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA202/01/0197), P(GA301/01/0186), P(IBS5004010), P(NC5955), Z(AV0Z5004920), Z(MSM 143300002)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Taslerová, Renata Kozubek, Michal Gajdušková, Pavla Cafourková, Alena Bártová, Eva Kozubek, Stanislav Falk, Martin Krontorád Koutná, Irena Lukášová, Emilie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	671951
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/02:00006554
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human genome structure; interphase cell nuclei (en)
http://linked.open.../riv/klicoveSlovo	human genome structure interphase cell nuclei
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[D895F60DFD3F]
http://linked.open...i/riv/nazevZdroje	Chromosoma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Investigation of the local control of gene expression using spectral microscopy and omage analysis techniques How the study spatial order of specific genetic loci in nuclei of healthy and malignant tissues can contribute to the diagnostics and treatment of solid tumors. Ionising radiation as a tool in the investigations of the cell nuclear structure and in the development of new techniques for ecology and medicine Development of new diagnostic techniques for oncology
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	111
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Lukášová, Emilie Falk, Martin Kozubek, Michal Krontorád Koutná, Irena Gajdušková, Pavla Taslerová, Renata Gaňová, Alena
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143300002
issn	0009-5915
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14330

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