About: Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture

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About: Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Growth, morphology and viability of C6 glioma cells were significantly altered only in fast growing cultures exposed to supratherapeutic doses of BSH (sodium mercaptoborate) for 48 to 72 h. Inhibition of cell proliferation and loss of semipermeability of plasma membrane of cells exposed to toxic doses of BSH were followed by apoptotic fragmentation of DNA in a small part of population. In the remaining lethally damaged cells the process of cell-destruction appeared to be inhibited. the higher uptake of BSH by transformed glial cells suggests that the BSH content in brain tumours in situ may be controlled not only by deffects in the hematoencephalic barrier but also by tumour cellphenotype. Growth, morphology and viability of C6 glioma cells were significantly altered only in fast growing cultures exposed to supratherapeutic doses of BSH (sodium mercaptoborate) for 48 to 72 h. Inhibition of cell proliferation and loss of semipermeability of plasma membrane of cells exposed to toxic doses of BSH were followed by apoptotic fragmentation of DNA in a small part of population. In the remaining lethally damaged cells the process of cell-destruction appeared to be inhibited. the higher uptake of BSH by transformed glial cells suggests that the BSH content in brain tumours in situ may be controlled not only by deffects in the hematoencephalic barrier but also by tumour cellphenotype. (en)
Title	Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture (en)
skos:prefLabel	Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture (en)
skos:notation	RIV/00216224:14310/97:00004073!RIV/2002/MZ0/143102/N
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NF5161)
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Španová, Alena
http://linked.open.../riv/druhVysledku	B - Odborná kniha
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	815863
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/97:00004073
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture (en)
http://linked.open.../riv/klicoveSlovo	uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture Toxicity
http://linked.open...ontrolniKodProRIV	[A4D309AEAEA4]
http://linked.open...i/riv/mistoVydani	Nizozemsko
http://linked.open...vEdiceCisloSvazku	Advances in neutron capture therapy. Volume II.
http://linked.open...i/riv/nazevZdroje	Toxicity, uptake and retention of sodium mercaptoborate (BSH) in glial and glioma cells in culture
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Radiosurgical lesion of the rat hippocampus using the Leksell gamma knife: relation between radiation dose and functional and structural damage.
http://linked.open...UplatneniVysledku	1997
http://linked.open...iv/tvurceVysledku	Lisá, Věra Mareš, Vladislav Španová, Alena Drahota, Zdeněk Burian, Jan Bačáková, Lenka Hnatowicz, Václav Kvítek, Jan
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Elsevier Science
https://schema.org/isbn	24-229-570
http://localhost/t...ganizacniJednotka	14310

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