About: Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans

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About: Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs11356-014-2932-6
Description	Organobromines of natural and artificial origin are omnipresent in aquatic and terrestrial environments. Although it is well established that exposure to high concentrations of organobromines are harmful to vertebrates, few studies have investigated the effect of environmentally realistic concentrations on invertebrates. Here, the nematode Caenorhabditis elegans was challenged with two organobromines, namely dibromoacetic acid (DBAA) and tetrabromobisphenol-A (TBBP), and monitored for changes in different life trait variables and global gene expression patterns. Fifty micromolar DBAA stimulated the growth and lifespan of the nematodes; however, the onset of reproduction was delayed. In contrast, TBBP changed the lifespan in a hormetic fashion, namely it was stimulated at 0.1 mu M but impaired at 50 mu M. The reproductive performance was even impaired at 2 mu M TBBP. Moreover, DBAA could not reduce the toxic effect of TBBP when applied as a mixture. Organobromines of natural and artificial origin are omnipresent in aquatic and terrestrial environments. Although it is well established that exposure to high concentrations of organobromines are harmful to vertebrates, few studies have investigated the effect of environmentally realistic concentrations on invertebrates. Here, the nematode Caenorhabditis elegans was challenged with two organobromines, namely dibromoacetic acid (DBAA) and tetrabromobisphenol-A (TBBP), and monitored for changes in different life trait variables and global gene expression patterns. Fifty micromolar DBAA stimulated the growth and lifespan of the nematodes; however, the onset of reproduction was delayed. In contrast, TBBP changed the lifespan in a hormetic fashion, namely it was stimulated at 0.1 mu M but impaired at 50 mu M. The reproductive performance was even impaired at 2 mu M TBBP. Moreover, DBAA could not reduce the toxic effect of TBBP when applied as a mixture. (en)
Title	Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans (en)
skos:prefLabel	Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans (en)
skos:notation	RIV/00216224:14310/14:00079339!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Jonáš, Adam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	51516
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00079339
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	C. elegans; Organobromine; Microarray; Lifespan; Reproduction; Hormesis (en)
http://linked.open.../riv/klicoveSlovo	Lifespan Microarray Reproduction C. elegans Hormesis Organobromine
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[F2819D02DF4B]
http://linked.open...i/riv/nazevZdroje	Environmental Science and Pollution Research
http://linked.open...in/vavai/riv/obor	DJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Jonáš, Adam Saul, Nadine Chakrabarti, Shumon Menzel, Ralph Sturzenbaum, Stephen R. Baberschke, Nora Lieke, Thora Steinberg, Christian E.W.
http://linked.open...ain/vavai/riv/wos	000340620400038
issn	0944-1344
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s11356-014-2932-6
http://localhost/t...ganizacniJednotka	14310

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