About: Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.hindawi.com/journals/bmri/2014/209670/
Description	Characteristic recurrent copy number aberrations (CNAs) play a key role in multiple myeloma (MM) pathogenesis and have important prognostic significance for MM patients. Array-based comparative genomic hybridization (aCGH) provides a powerful tool for genome-wide classification of CNAs and thus should be implemented into MM routine diagnostics. We demonstrate the possibility of effective utilization of oligonucleotide-based aCGH in 91 MM patients. Chromosomal aberrations associated with effect on the prognosis of MM were initially evaluated by I-FISH and were found in 93.4% (85/91). Incidence of hyperdiploidy was 49.5% (45/91); del(13)(q14) was detected in 57.1% (52/91); gain(1)(q21) occurred in 58.2% (53/91); del(17)(p13) was observed in 15.4% (14/91); and t(4;14)(p16;q32) was found in 18.6% (16/86). Genome-wide screening using Agilent 44K aCGH microarrays revealed copy number alterations in 100% (91/91). Most common deletions were found at 13q (58.9%), 1p (39.6%), and 8p (31. Characteristic recurrent copy number aberrations (CNAs) play a key role in multiple myeloma (MM) pathogenesis and have important prognostic significance for MM patients. Array-based comparative genomic hybridization (aCGH) provides a powerful tool for genome-wide classification of CNAs and thus should be implemented into MM routine diagnostics. We demonstrate the possibility of effective utilization of oligonucleotide-based aCGH in 91 MM patients. Chromosomal aberrations associated with effect on the prognosis of MM were initially evaluated by I-FISH and were found in 93.4% (85/91). Incidence of hyperdiploidy was 49.5% (45/91); del(13)(q14) was detected in 57.1% (52/91); gain(1)(q21) occurred in 58.2% (53/91); del(17)(p13) was observed in 15.4% (14/91); and t(4;14)(p16;q32) was found in 18.6% (16/86). Genome-wide screening using Agilent 44K aCGH microarrays revealed copy number alterations in 100% (91/91). Most common deletions were found at 13q (58.9%), 1p (39.6%), and 8p (31. (en)
Title	Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience (en)
skos:prefLabel	Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience (en)
skos:notation	RIV/00216224:14310/14:00078288!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0183), P(NT11154), P(NT13190), P(NT13492), S, Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	MAY
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Fröhlich, Jan Smetana, Jan Almáši, Martina Vranová, Vladimíra Kuglík, Petr Hájek, Roman Němec, Pavel Mikulášová, Aneta Grešliková, Henrieta Zaoralová, Romana Kupská, Renata
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	18147
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00078288
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple myeloma; genome-wide profiling; array-CGH; cytogenetics; FISH (en)
http://linked.open.../riv/klicoveSlovo	genome-wide profiling FISH array-CGH Multiple myeloma cytogenetics
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C86A4F48A284]
http://linked.open...i/riv/nazevZdroje	BioMed Research International
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of B cell lineage mitotic disruptions in multiple myeloma Center of Experimental Biomedicine Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma Role of genetic abnormalities in development and progression of precancerosis monoclonal gammopathy of undetermined significance
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	Neuveden
http://linked.open...iv/tvurceVysledku	Adam, Zdeněk Hájek, Roman Kuglík, Petr Pour, Luděk Smetana, Jan Němec, Pavel Mikulášová, Aneta Sandecká, Viera Zahradová, Lenka Fröhlich, Jan Grešliková, Henrieta Zaoralová, Romana Kupská, Renata Vallová, Vladimíra Almaši, Martina
http://linked.open...ain/vavai/riv/wos	000337382600001
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	2314-6133
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2014/209670
http://localhost/t...ganizacniJednotka	14310

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