About: Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused to a chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellular targets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells. Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused to a chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellular targets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells. (en)
Title	Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy (en)
skos:prefLabel	Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy (en)
skos:notation	RIV/00216224:14310/14:00077288!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(ED2.1.00/03.0101), P(EE2.3.20.0183), P(NT13441), S
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Nehybová, Tereza Beneš, Petr Šmarda, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	36754
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00077288
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cancer; cellular target; coumestrol; coumestan; glycyrol; psoralidin; therapy; wedelolactone (en)
http://linked.open.../riv/klicoveSlovo	cellular target coumestan coumestrol glycyrol psoralidin cancer therapy wedelolactone
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[3DBE15DF3841]
http://linked.open...i/riv/nazevZdroje	Anti-Cancer Agents in Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Experimental Biomedicine Regional Centre for Applied Molecular Oncology (RECAMO) Myb Protein Family Expression in Colorectal Adenocarcinoma and its Correlation to Metastatic Potential St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Beneš, Petr Šmarda, Jan Nehybová, Tereza
http://linked.open...ain/vavai/riv/wos	000345226600006
issn	1871-5206
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/1871520614666140713172949
http://localhost/t...ganizacniJednotka	14310

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