About: Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.

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About: Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract
Description	Metastases are responsible for most of the cases of death in patients with solid tumors. There is thus an urgent clinical need of better understanding the exact molecular mechanisms and finding novel therapeutics targets and biomarkers of metastatic disease of various tumors. Metastases are formed in a complicated biological process called metastatic cascade. Up to now, proteomics has enabled the identification of number of metastasis-associated proteins and potential biomarkers in cancer tissues, microdissected cells, model systems, and secretomes. Expression profiles and biological role of key proteins were confirmed in verification and functional experiments. This communication reviews these observations and analyses the methodological aspects of the proteomics approaches used. Moreover, it reviews contribution of current proteomics in the field of functional characterization and interactome analysis of proteins involved in various events in metastatic cascade. Metastases are responsible for most of the cases of death in patients with solid tumors. There is thus an urgent clinical need of better understanding the exact molecular mechanisms and finding novel therapeutics targets and biomarkers of metastatic disease of various tumors. Metastases are formed in a complicated biological process called metastatic cascade. Up to now, proteomics has enabled the identification of number of metastasis-associated proteins and potential biomarkers in cancer tissues, microdissected cells, model systems, and secretomes. Expression profiles and biological role of key proteins were confirmed in verification and functional experiments. This communication reviews these observations and analyses the methodological aspects of the proteomics approaches used. Moreover, it reviews contribution of current proteomics in the field of functional characterization and interactome analysis of proteins involved in various events in metastatic cascade. (en)
Title	Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges. Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges. (en)
skos:prefLabel	Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges. Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges. (en)
skos:notation	RIV/00216224:14310/14:00074977!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0101), S
http://linked.open...iv/cisloPeriodika	4-5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Struhárová, Iva Bouchal, Pavel Dvořáková, Monika Faktor, Jakub Maryáš, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	40493
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00074977
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Biomarkers; Biomedicine; Functional studies; Metastasis; Surface proteins (en)
http://linked.open.../riv/klicoveSlovo	Biomarkers Metastasis Biomedicine Functional studies Surface proteins
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1BED49A780A7]
http://linked.open...i/riv/nazevZdroje	Proteomics
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Bouchal, Pavel Struhárová, Iva Dvořáková, Monika Faktor, Jakub Maryáš, Josef Grell, Peter
http://linked.open...ain/vavai/riv/wos	000332341200008
issn	1615-9853
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/pmic.201300264
http://localhost/t...ganizacniJednotka	14310

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