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  • Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression.
  • Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression. (en)
Title
  • Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
  • Transgelins, cytoskeletal proteins implicated in different aspects of cancer development (en)
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  • Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
  • Transgelins, cytoskeletal proteins implicated in different aspects of cancer development (en)
skos:notation
  • RIV/00216224:14310/14:00074976!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(ED2.1.00/03.0101), S
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
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  • 51022
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  • RIV/00216224:14310/14:00074976
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  • cancer; cytoskeleton; differentiation; proliferation; transgelin; transgelin-2 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
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  • [3BADA50099C4]
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  • Expert Review of Proteomics
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  • 11
http://linked.open...iv/tvurceVysledku
  • Bouchal, Pavel
  • Dvořáková, Monika
  • Nenutil, Rudolf
http://linked.open...ain/vavai/riv/wos
  • 000335649300004
issn
  • 1478-9450
number of pages
http://bibframe.org/vocab/doi
  • 10.1586/14789450.2014.860358
http://localhost/t...ganizacniJednotka
  • 14310
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