About: Retinoid-like activity and teratogenic effects of cyanobacterial exudates

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About: Retinoid-like activity and teratogenic effects of cyanobacterial exudates Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0166445X14002355
Description	Given the essential role of retinoids for vertebrate development this has raised concerns about a potential risk for vertebrates exposed to retinoids during cyanobacterial blooms. Our study focuses on extracellular compounds produced by phytoplankton cells (exudates). In order to address the capacity for the production of retinoids or compounds with retinoid-like activity we compared the exudates of ten cyanobacteria and algae using in vitro reporter gene assay. Exudates of three cyanobacterial species showed retinoid-like activity in the range of 269-2265 ng retinoid equivalents (REQ)/L, while there was no detectable activity in exudates of the investigated algal species. The exudates of one green alga (Desmodesmus quadricaudus) and the two cyanobacterial species with greatest REQ levels, Microgstis aeruginosa and Cylindrospermopsis raciborskii, were selected for testing of the potential relation of retinoid-like activity to developmental toxicity in zebrafish embryos. Given the essential role of retinoids for vertebrate development this has raised concerns about a potential risk for vertebrates exposed to retinoids during cyanobacterial blooms. Our study focuses on extracellular compounds produced by phytoplankton cells (exudates). In order to address the capacity for the production of retinoids or compounds with retinoid-like activity we compared the exudates of ten cyanobacteria and algae using in vitro reporter gene assay. Exudates of three cyanobacterial species showed retinoid-like activity in the range of 269-2265 ng retinoid equivalents (REQ)/L, while there was no detectable activity in exudates of the investigated algal species. The exudates of one green alga (Desmodesmus quadricaudus) and the two cyanobacterial species with greatest REQ levels, Microgstis aeruginosa and Cylindrospermopsis raciborskii, were selected for testing of the potential relation of retinoid-like activity to developmental toxicity in zebrafish embryos. (en)
Title	Retinoid-like activity and teratogenic effects of cyanobacterial exudates Retinoid-like activity and teratogenic effects of cyanobacterial exudates (en)
skos:prefLabel	Retinoid-like activity and teratogenic effects of cyanobacterial exudates Retinoid-like activity and teratogenic effects of cyanobacterial exudates (en)
skos:notation	RIV/00216224:14310/14:00074441!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GAP503/12/0553), S
http://linked.open...iv/cisloPeriodika	OCTOBER
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Jonáš, Adam Nováková, Kateřina Buráňová, Veronika Hilscherová, Klára Kohoutek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	42558
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00074441
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyanobacteria; Developmental toxicity; Retinoids; Zebrafish embryo; All-trans retinoic acid (en)
http://linked.open.../riv/klicoveSlovo	Retinoids Cyanobacteria Developmental toxicity Zebrafish embryo All-trans retinoic acid
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3392EB8D27C4]
http://linked.open...i/riv/nazevZdroje	Aquatic toxicology
http://linked.open...in/vavai/riv/obor	DJ
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Endocrine disruptive potential of cyanobacterial metabolites
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	155
http://linked.open...iv/tvurceVysledku	Hilscherová, Klára Nováková, Kateřina Kohoutek, Jiří Jonáš, Adam Fetter, Eva Scholz, Stefan Buráňová, Veronika
http://linked.open...ain/vavai/riv/wos	000342245300032
issn	0166-445X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.aquatox.2014.06.022
http://localhost/t...ganizacniJednotka	14310

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