About: Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method     Goto   Sponge   NotDistinct   Permalink

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  • Enantioselective discrimination is an important phenomenon influencing pharmacokinetics and pharmacodynamics of chiral drugs in humans and animals. Metabolism appraisal of single enantiomers of every drug candidate compound thus constitutes the inseparable part of LADME/tox screening. Capillary electrophoresis represents a promising technique in the field of in vitro enzyme assays due to miniscule sample consumption, simple implementation of chiral separations and high-throughput by automation. An optimized and economical capillary electrophoretic method for on-line studies of the enantioselective drug metabolism mediated by cytochrome P450 3A4 enzyme (CYP3A4) is introduced.
  • Enantioselective discrimination is an important phenomenon influencing pharmacokinetics and pharmacodynamics of chiral drugs in humans and animals. Metabolism appraisal of single enantiomers of every drug candidate compound thus constitutes the inseparable part of LADME/tox screening. Capillary electrophoresis represents a promising technique in the field of in vitro enzyme assays due to miniscule sample consumption, simple implementation of chiral separations and high-throughput by automation. An optimized and economical capillary electrophoretic method for on-line studies of the enantioselective drug metabolism mediated by cytochrome P450 3A4 enzyme (CYP3A4) is introduced. (en)
Title
  • Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method
  • Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method (en)
skos:prefLabel
  • Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method
  • Kinetic Study OF Ketamine N-Demethylation Mediated by On-Line Enantioselective Capillary Electrophoresis Method (en)
skos:notation
  • RIV/00216224:14310/14:00074205!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita
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  • P(GAP206/10/0057), S
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  • 24244
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  • RIV/00216224:14310/14:00074205
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  • Kapilární elektroforéza; Enantioselektivní separace; Cytochrom P450; CYP3A4; Ketamin (en)
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  • [514316080FD4]
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  • Brno
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  • Brno
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  • 11 th International Interdisciplinary Meeting on Bioanalysis CECE 2014
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  • Glatz, Zdeněk
  • Řemínek, Roman
  • Thormann, Wolfgang
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number of pages
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  • Institute of Analytical Chemistry AS CR, v. v. i., Brno, Česká republika,
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  • 9788090495920
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  • 14310
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