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rdf:type
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Description
| - Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/beta-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization, or interactions of target proteins. To identify regulators of the Wnt/beta-catenin pathway, we performed an RNA interference screen in Caenorhabditis elegans and identified the HECT domain-containing ubiquitin ligase EEL-1 as an inhibitor of Wnt signaling. In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in cells stimulated with Wnt3a or in cells that overexpressed casein kinase 1 (CK1) or a constitutively active mutant of the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6).
- Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/beta-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization, or interactions of target proteins. To identify regulators of the Wnt/beta-catenin pathway, we performed an RNA interference screen in Caenorhabditis elegans and identified the HECT domain-containing ubiquitin ligase EEL-1 as an inhibitor of Wnt signaling. In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in cells stimulated with Wnt3a or in cells that overexpressed casein kinase 1 (CK1) or a constitutively active mutant of the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6). (en)
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Title
| - Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway.
- Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. (en)
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skos:prefLabel
| - Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway.
- Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. (en)
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skos:notation
| - RIV/00216224:14310/14:00073568!RIV15-MSM-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GA204/09/0498), P(GD204/09/H058), S, Z(MSM0021622430)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/14:00073568
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bryja, Vítězslav
- Zdráhal, Zbyněk
- Ganji, Sri Ranjani
- Korswagen, Hendrik C.
- de Groot, Reinoud E. A.
- Bernatík, Ondřej
- Šedová, Kateřina
- Dale, Trevor C
- Dhople, Vishnu M.
- Lloyd-Lewis, Bethan
- Seipel, Katja
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1126/scisignal.2004985
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http://localhost/t...ganizacniJednotka
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