About: Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway.

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About: Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/beta-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization, or interactions of target proteins. To identify regulators of the Wnt/beta-catenin pathway, we performed an RNA interference screen in Caenorhabditis elegans and identified the HECT domain-containing ubiquitin ligase EEL-1 as an inhibitor of Wnt signaling. In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in cells stimulated with Wnt3a or in cells that overexpressed casein kinase 1 (CK1) or a constitutively active mutant of the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6). Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/beta-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization, or interactions of target proteins. To identify regulators of the Wnt/beta-catenin pathway, we performed an RNA interference screen in Caenorhabditis elegans and identified the HECT domain-containing ubiquitin ligase EEL-1 as an inhibitor of Wnt signaling. In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in cells stimulated with Wnt3a or in cells that overexpressed casein kinase 1 (CK1) or a constitutively active mutant of the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6). (en)
Title	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. (en)
skos:prefLabel	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. (en)
skos:notation	RIV/00216224:14310/14:00073568!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA204/09/0498), P(GD204/09/H058), S, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	317
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Bernatík, Ondřej Bryja, Vítězslav Zdráhal, Zbyněk Nováková, Kateřina Ganji, Sri Ranjani
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	20019
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00073568
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway. (en)
http://linked.open.../riv/klicoveSlovo	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway.
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6781110E8862]
http://linked.open...i/riv/nazevZdroje	Science Signaling
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Intercellular signalling in development and disease Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Zdráhal, Zbyněk Ganji, Sri Ranjani Korswagen, Hendrik C. de Groot, Reinoud E. A. Bernatík, Ondřej Šedová, Kateřina Dale, Trevor C Dhople, Vishnu M. Lloyd-Lewis, Bethan Seipel, Katja
http://linked.open...ain/vavai/riv/wos	000333557500002
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1937-9145
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1126/scisignal.2004985
http://localhost/t...ganizacniJednotka	14310

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