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  • This article describes the outcome and follow up discussions of an expert group meeting (Amsterdam, October 9, 2009) on the applicability of toxicity profiling for diagnostic environmental risk assessment. A toxicity profile was defined as a toxicological fingerprint of a sample, ranging froma pure compound to a complex mixture, obtained by testing the sample or its extract for its activity toward a battery of biological endpoints. The expert group concluded that toxicity profiling is an effective first tier tool for screening the integrated hazard of complex environmental mixtures with known and unknown toxicologically active constituents. In addition, toxicity profiles can be used for prioritization of sampling locations, for identification of hot spots, and in combination with effect directed analysis (EDA) or toxicity identification and evaluation (TIE) approaches for establishing cause effect relationships by identifying emerging pollutants responsible for the observed toxic potency.
  • This article describes the outcome and follow up discussions of an expert group meeting (Amsterdam, October 9, 2009) on the applicability of toxicity profiling for diagnostic environmental risk assessment. A toxicity profile was defined as a toxicological fingerprint of a sample, ranging froma pure compound to a complex mixture, obtained by testing the sample or its extract for its activity toward a battery of biological endpoints. The expert group concluded that toxicity profiling is an effective first tier tool for screening the integrated hazard of complex environmental mixtures with known and unknown toxicologically active constituents. In addition, toxicity profiles can be used for prioritization of sampling locations, for identification of hot spots, and in combination with effect directed analysis (EDA) or toxicity identification and evaluation (TIE) approaches for establishing cause effect relationships by identifying emerging pollutants responsible for the observed toxic potency. (en)
Title
  • Expert opinion on toxicity profiling – report from a NORMAN expert group meeting.
  • Expert opinion on toxicity profiling – report from a NORMAN expert group meeting. (en)
skos:prefLabel
  • Expert opinion on toxicity profiling – report from a NORMAN expert group meeting.
  • Expert opinion on toxicity profiling – report from a NORMAN expert group meeting. (en)
skos:notation
  • RIV/00216224:14310/13:00071503!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED0001/01/01)
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  • 74254
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/13:00071503
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  • Toxicity profile; Effect directed analysis; Water framework directive; Bioassays; Biomarkers (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [E649C1C63988]
http://linked.open...i/riv/nazevZdroje
  • Integrated Environmental Assessment and Management
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  • 9
http://linked.open...iv/tvurceVysledku
  • Bláha, Luděk
  • Hamers, T.
  • Hylland, K.
  • Legler, J.
  • Leonards, P.E.G.
  • Marigomez, I.
  • Schipper, C. A.
  • Segner, H.
  • Vethaak, D.
  • Witters, H.
  • de Zwart, D.
issn
  • 1551-3777
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/ieam.1395
http://localhost/t...ganizacniJednotka
  • 14310
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