About: Interaction of oligonucleotides with benzo[c]phenanthridine alkaloid sanguilutine

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About: Interaction of oligonucleotides with benzo[c]phenanthridine alkaloid sanguilutine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.2478%2Fs11696-013-0340-x
Description	Benzo[c]phenanthridine alkaloid sanguilutine (present in plant Sanguinaria canadensis) was extracted and separated from the plant material (dried roots). Interaction of the positively charged iminium form of alkaloid with double stranded DNA is reported in this article. Significant changes in fluorescence properties in the presence or absence of various oligonucleotides have allowed us to study this system by means of luminescence spectroscopy. Results have shown that interaction with different double stranded oligonucleotides is not specific to A-T or G-C base pairs and also no preference of homogeneous or heterogeneous base composition of strands was found. Association constants (log K) were calculated to be in the range of 5.11 to 6.16. The response of luminescence intensity at 610 nm to low concentrations of double stranded DNA was found to be linear and can be potentially used for fluorometric quantification of DNA. The limit of detection was estimated to be 120 ng. Benzo[c]phenanthridine alkaloid sanguilutine (present in plant Sanguinaria canadensis) was extracted and separated from the plant material (dried roots). Interaction of the positively charged iminium form of alkaloid with double stranded DNA is reported in this article. Significant changes in fluorescence properties in the presence or absence of various oligonucleotides have allowed us to study this system by means of luminescence spectroscopy. Results have shown that interaction with different double stranded oligonucleotides is not specific to A-T or G-C base pairs and also no preference of homogeneous or heterogeneous base composition of strands was found. Association constants (log K) were calculated to be in the range of 5.11 to 6.16. The response of luminescence intensity at 610 nm to low concentrations of double stranded DNA was found to be linear and can be potentially used for fluorometric quantification of DNA. The limit of detection was estimated to be 120 ng. (en)
Title	Interaction of oligonucleotides with benzo[c]phenanthridine alkaloid sanguilutine Interaction of oligonucleotides with benzo[c]phenanthridine alkaloid sanguilutine (en)
skos:prefLabel	Interaction of oligonucleotides with benzo[c]phenanthridine alkaloid sanguilutine Interaction of oligonucleotides with benzo[c]phenanthridine alkaloid sanguilutine (en)
skos:notation	RIV/00216224:14310/13:00070284!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(LH12176), S
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Rybáková, Stanislava Táborská, Eva Táborský, Petr Kantorová, Jana Pěnčíková, Kristýna Rájecký, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	80647
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00070284
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	alkaloid; sanguilutine; DNA; intercalation; fluorescent probe; luminescence (en)
http://linked.open.../riv/klicoveSlovo	sanguilutine intercalation DNA fluorescent probe luminescence alkaloid
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[6DC9BB097D7E]
http://linked.open...i/riv/nazevZdroje	Chemical Papers
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Benzophenanthridine alkaloids - study of their effects on cellular and molecular level
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Táborská, Eva Táborský, Petr Pěnčíková, Kristýna Urbanová, Jana Rájecký, Michal Gargallo, Raimundo Rybáková, Stanislava
http://linked.open...ain/vavai/riv/wos	000314882900012
issn	0366-6352
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.2478/s11696-013-0340-x
http://localhost/t...ganizacniJednotka	14310

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