About: High Frequency of Temperature-Sensitive Mutants of p53 in Glioblastoma

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About: High Frequency of Temperature-Sensitive Mutants of p53 in Glioblastoma Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glioblastoma is the most common and the most aggressive type of brain cancer. Aberrations of the RTK/RAS/PI3K-, p53-, and RB cell signaling pathways were recognized as a core requirement for pathogenesis of glioblastoma. The p53 tumor suppressor functions as a transcription factor transactivating expression of its target genes in response to various stress stimuli. We determined the p53 status in 36 samples of glioblastoma by functional analyses FASAY and split assay. Seventeen p53 mutations were detected and further analyzed by cDNA and gDNA sequencing in 17 patients (47.2 %). Fifteen (88.2 %) of the mutations were missense mutations causing amino acid substitutions, seven of them exhibited temperature-sensitivity. Two mutations were determined as short deletions, one of them causing formation of premature termination codon in position 247. Fluorescent in situ hybridization revealed the loss of the p53-specific 17p13.3 locus in four of 33 analyzed samples (12 %). Glioblastoma is the most common and the most aggressive type of brain cancer. Aberrations of the RTK/RAS/PI3K-, p53-, and RB cell signaling pathways were recognized as a core requirement for pathogenesis of glioblastoma. The p53 tumor suppressor functions as a transcription factor transactivating expression of its target genes in response to various stress stimuli. We determined the p53 status in 36 samples of glioblastoma by functional analyses FASAY and split assay. Seventeen p53 mutations were detected and further analyzed by cDNA and gDNA sequencing in 17 patients (47.2 %). Fifteen (88.2 %) of the mutations were missense mutations causing amino acid substitutions, seven of them exhibited temperature-sensitivity. Two mutations were determined as short deletions, one of them causing formation of premature termination codon in position 247. Fluorescent in situ hybridization revealed the loss of the p53-specific 17p13.3 locus in four of 33 analyzed samples (12 %). (en)
Title	High Frequency of Temperature-Sensitive Mutants of p53 in Glioblastoma High Frequency of Temperature-Sensitive Mutants of p53 in Glioblastoma (en)
skos:prefLabel	High Frequency of Temperature-Sensitive Mutants of p53 in Glioblastoma High Frequency of Temperature-Sensitive Mutants of p53 in Glioblastoma (en)
skos:notation	RIV/00216224:14310/13:00068188!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ševčíková, Sabina Šmarda, Jan Michálek, Jaroslav Kubiczková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	77340
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00068188
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Glioblastoma; p53 tumor suppressor; FASAY; Temperature-sensitive mutation; p53 gene deletion (en)
http://linked.open.../riv/klicoveSlovo	Glioblastoma FASAY Temperature-sensitive mutation p53 gene deletion p53 tumor suppressor
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CD02E96F5CF0]
http://linked.open...i/riv/nazevZdroje	PATHOLOGY & ONCOLOGY RESEARCH
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Michálek, Jaroslav Ravčuková, Barbora Šmarda, Jan Ševčíková, Sabina Křen, Leoš Svitáková, Miluše Šmardová, Jana Vybíhal, Václav Kubiczková, Lenka Lišková, Květoslava
http://linked.open...ain/vavai/riv/wos	000321973600010
issn	1219-4956
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s12253-012-9596-7
http://localhost/t...ganizacniJednotka	14310

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