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rdf:type
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Description
| - Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins (APPs) are intensely investigated because of their link to Alzheimer's disease (AD). APP's in vivo function in the brain and the mechanisms underlying it remain unclear and controversial. Drosophila possesses a single APP homologue called APP Like, or APPL. APPL is expressed in all neurons throughout development, but has no established function in neuronal development. We therefore investigated the role of Drosophila APPL during brain development. We find that APPL is involved in the development of the Mushroom Body alfa beta neurons and, in particular, is required cell-autonomously for the beta-axons and non-cell autonomously for the alfa-axons growth.
- Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins (APPs) are intensely investigated because of their link to Alzheimer's disease (AD). APP's in vivo function in the brain and the mechanisms underlying it remain unclear and controversial. Drosophila possesses a single APP homologue called APP Like, or APPL. APPL is expressed in all neurons throughout development, but has no established function in neuronal development. We therefore investigated the role of Drosophila APPL during brain development. We find that APPL is involved in the development of the Mushroom Body alfa beta neurons and, in particular, is required cell-autonomously for the beta-axons and non-cell autonomously for the alfa-axons growth. (en)
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Title
| - The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.
- The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. (en)
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skos:prefLabel
| - The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.
- The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. (en)
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skos:notation
| - RIV/00216224:14310/13:00067038!RIV14-MSM-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GA204/09/0498), P(GAP301/11/0747), S, Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/13:00067038
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - PLANAR CELL POLARITY; ALZHEIMERS-DISEASE; AXONAL-TRANSPORT; FAMILY-MEMBERS; DEFICIENT MICE; GENE; APP; HYPOTHESIS; NEURON; THERAPEUTICS (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bryja, Vítězslav
- Tmejová, Kateřina
- Atak, Zeynep Kalender
- Claeys, Annelies
- De Strooper, Bart
- Dura, Jean-Maurice
- Hassan, Bassem A.
- Janovská, Pavlína
- Okray, Zeynep
- Reynaud, Elodie
- Soldano, Alessia
- Yan, Jiekun
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1371/journal.pbio.1001562
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http://localhost/t...ganizacniJednotka
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