About: Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth.

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About: Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cationic specificity which follows the Hofmeister series has been established for the catalytic efficiency of haloalkane dehalogenase LinB by a combination of molecular dynamics simulations and enzyme kinetic experiments. Simulations provided a detailed molecular picture of cation interactions with negatively charged residues on the protein surface, particularly at the tunnel mouth leading to the enzyme active site. On the basis of the binding affinities, cations were ordered as Na+ > K+ > Rb+ > Cs+. In agreement with this result, a steady-state kinetic analysis disclosed that the smaller alkali cations influence formation and productivity of enzyme–substrate complexes more efficiently than the larger ones. Cationic specificity which follows the Hofmeister series has been established for the catalytic efficiency of haloalkane dehalogenase LinB by a combination of molecular dynamics simulations and enzyme kinetic experiments. Simulations provided a detailed molecular picture of cation interactions with negatively charged residues on the protein surface, particularly at the tunnel mouth leading to the enzyme active site. On the basis of the binding affinities, cations were ordered as Na+ > K+ > Rb+ > Cs+. In agreement with this result, a steady-state kinetic analysis disclosed that the smaller alkali cations influence formation and productivity of enzyme–substrate complexes more efficiently than the larger ones. (en)
Title	Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth. Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth. (en)
skos:prefLabel	Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth. Cation-Specific Effects on Enzymatic Catalysis Driven by Interactions at the Tunnel Mouth. (en)
skos:notation	RIV/00216224:14310/13:00066616!RIV14-GA0-14310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.100/02/0123), P(GAP207/12/0775), P(GBP208/12/G016)
http://linked.open...iv/cisloPeriodika	21
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Štěpánková, Veronika Damborský, Jiří Chaloupková, Radka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	64423
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00066616
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Tunnel Mouth; Interactions (en)
http://linked.open.../riv/klicoveSlovo	Interactions Tunnel Mouth
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6A0957E3A8D4]
http://linked.open...i/riv/nazevZdroje	Journal of Physical Chemistry B
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Controlling structure and function of biomolecules at the molecular scale: theory meets experiment Strukturně-funkční vztahy haloalkan dehalogenas St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	117
http://linked.open...iv/tvurceVysledku	Chaloupková, Radka Damborský, Jiří Štěpánková, Veronika Jungwirth, P. Heyda, J. Paterova, J.
http://linked.open...ain/vavai/riv/wos	000319896800006
issn	1520-6106
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/jp401506v
http://localhost/t...ganizacniJednotka	14310

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