About: Synthesis, activity and interaction of nitrone functionalized PAH derivatives     Goto   Sponge   NotDistinct   Permalink

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  • Polycyclic aromatic hydrocarbons (PAHs) are widely studied. Their carcinogenic properties are well known. In a sharp contrast to those effects the functionalized PAHs were recently identified as important candidates for cancer therapy.1 Mechanism of action is often simplified and studied at the DNA level. A lot of discussion has been held about groups being introduced to the PAHs structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. According to our experience in nitrone chemistry2 the synthetic design of new PAHs derivatives was achieved by a multicomponent reaction of compounds 1-3.
  • Polycyclic aromatic hydrocarbons (PAHs) are widely studied. Their carcinogenic properties are well known. In a sharp contrast to those effects the functionalized PAHs were recently identified as important candidates for cancer therapy.1 Mechanism of action is often simplified and studied at the DNA level. A lot of discussion has been held about groups being introduced to the PAHs structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. According to our experience in nitrone chemistry2 the synthetic design of new PAHs derivatives was achieved by a multicomponent reaction of compounds 1-3. (en)
Title
  • Synthesis, activity and interaction of nitrone functionalized PAH derivatives
  • Synthesis, activity and interaction of nitrone functionalized PAH derivatives (en)
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  • Synthesis, activity and interaction of nitrone functionalized PAH derivatives
  • Synthesis, activity and interaction of nitrone functionalized PAH derivatives (en)
skos:notation
  • RIV/00216224:14310/13:00066251!RIV14-GA0-14310___
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  • P(GA203/09/1345)
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  • 109454
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  • RIV/00216224:14310/13:00066251
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  • nitrone; PAH substitution; molecular modeling; activity testing in vitro (en)
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  • [9E08D8CCE963]
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  • Buchlovič, Marian
  • Potáček, Milan
  • Kříž, Zdeněk
  • Hofr, Ctirad
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  • 14310
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