About: New Capillary Electrophoretic Method for On-line Screenings of Drug Metabolism Mediated by Cytochrome P450 Enzymes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A new method for the determination of kinetic and inhibition parameters of cytochromes P450 reactions by means of on-line capillary electrophoresis was developed. It is based on transverse diffusion of laminar flow profiles methodology introduced by Krylov et al. which injection procedure was modified. The solutions of an enzyme and its substrates are injected by hydrodynamic pressure as a series of repeated consecutive plugs. Proposed injection of 3 plugs of enzyme surrounded with plugs of substrates represents a certain trade-off to obtain the reaction mixture with the satisfying homogeneity by the short injection procedure as possible. Mathematical modelling confirmed the assumption of a consistent distribution of reactants in the final reaction mixture. A new method for the determination of kinetic and inhibition parameters of cytochromes P450 reactions by means of on-line capillary electrophoresis was developed. It is based on transverse diffusion of laminar flow profiles methodology introduced by Krylov et al. which injection procedure was modified. The solutions of an enzyme and its substrates are injected by hydrodynamic pressure as a series of repeated consecutive plugs. Proposed injection of 3 plugs of enzyme surrounded with plugs of substrates represents a certain trade-off to obtain the reaction mixture with the satisfying homogeneity by the short injection procedure as possible. Mathematical modelling confirmed the assumption of a consistent distribution of reactants in the final reaction mixture. (en)
Title	New Capillary Electrophoretic Method for On-line Screenings of Drug Metabolism Mediated by Cytochrome P450 Enzymes New Capillary Electrophoretic Method for On-line Screenings of Drug Metabolism Mediated by Cytochrome P450 Enzymes (en)
skos:prefLabel	New Capillary Electrophoretic Method for On-line Screenings of Drug Metabolism Mediated by Cytochrome P450 Enzymes New Capillary Electrophoretic Method for On-line Screenings of Drug Metabolism Mediated by Cytochrome P450 Enzymes (en)
skos:notation	RIV/00216224:14310/13:00066068!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(EE2.3.20.0182), P(GAP206/10/0057), S
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Glatz, Zdeněk Zeisbergerová, Marta Řemínek, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	91532
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00066068
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CE; Cytochrome P450; Drug Metabolism (en)
http://linked.open.../riv/klicoveSlovo	Cytochrome P450 Drug Metabolism CE
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[CEF0A594DCE1]
http://linked.open...i/riv/nazevZdroje	Electrophoresis
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of Multidisciplinary Research and Educational Centrum for Bioanalytical Technologies Miniaturised on-line drug-metabolism system based on capillary electrophoresis
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Glatz, Zdeněk Langmajerová, Monika Zeisbergerová, Marta Řemínek, Roman
http://linked.open...ain/vavai/riv/wos	000327590900013
issn	0173-0835
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/elps.201300124
http://localhost/t...ganizacniJednotka	14310

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