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rdf:type
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Description
| - Pharmaceutical industry currently needs to screen extensive compound libraries within pre-clinical stages of drug development. Capillary electrophoresis has become a well-established analytical technique during the last two decades. In spite of the fact that capillary electrophoresis offers a number of favorable features for high-throughput analytical assays, it is still less important than chromatographic techniques in drug development programs. Hence, the main aim of this chapter is to discuss the practical limitations of capillary electrophoresis utilization and suggest ways to overcome these constraints. This is illustrated with a practical example namely the introduction of a method allowing rapid characterization of a compound’s stability against human liver microsomes. NADP+ production monitoring was adopted to ensure generic applicability of the method.
- Pharmaceutical industry currently needs to screen extensive compound libraries within pre-clinical stages of drug development. Capillary electrophoresis has become a well-established analytical technique during the last two decades. In spite of the fact that capillary electrophoresis offers a number of favorable features for high-throughput analytical assays, it is still less important than chromatographic techniques in drug development programs. Hence, the main aim of this chapter is to discuss the practical limitations of capillary electrophoresis utilization and suggest ways to overcome these constraints. This is illustrated with a practical example namely the introduction of a method allowing rapid characterization of a compound’s stability against human liver microsomes. NADP+ production monitoring was adopted to ensure generic applicability of the method. (en)
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Title
| - Application of capillary electrophoresis for high-throughput screening of drug metabolism
- Application of capillary electrophoresis for high-throughput screening of drug metabolism (en)
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skos:prefLabel
| - Application of capillary electrophoresis for high-throughput screening of drug metabolism
- Application of capillary electrophoresis for high-throughput screening of drug metabolism (en)
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skos:notation
| - RIV/00216224:14310/13:00066018!RIV14-MSM-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(EE2.3.20.0182), P(GAP206/10/0057), S
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/13:00066018
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Capillary electrophoresis; human liver microsomes; cytochrome P450 enzyme; drug development; metabolic stability (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/mistoVydani
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http://linked.open...vEdiceCisloSvazku
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http://linked.open...i/riv/nazevZdroje
| - Capillary Electrophoresis and Microchip Capillary Electrophoresis: Principles, Applications, and Limitations
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...v/pocetStranKnihy
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Glatz, Zdeněk
- Wang, Xu
- Řemínek, Roman
- Hoogmartens, Jos
- Pauwels, Jochen
- Van Schepdael, Ann
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1002/9781118530009.ch17
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http://purl.org/ne...btex#hasPublisher
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https://schema.org/isbn
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http://localhost/t...ganizacniJednotka
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