About: Application of capillary electrophoresis for high-throughput screening of drug metabolism

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pharmaceutical industry currently needs to screen extensive compound libraries within pre-clinical stages of drug development. Capillary electrophoresis has become a well-established analytical technique during the last two decades. In spite of the fact that capillary electrophoresis offers a number of favorable features for high-throughput analytical assays, it is still less important than chromatographic techniques in drug development programs. Hence, the main aim of this chapter is to discuss the practical limitations of capillary electrophoresis utilization and suggest ways to overcome these constraints. This is illustrated with a practical example namely the introduction of a method allowing rapid characterization of a compound’s stability against human liver microsomes. NADP+ production monitoring was adopted to ensure generic applicability of the method. Pharmaceutical industry currently needs to screen extensive compound libraries within pre-clinical stages of drug development. Capillary electrophoresis has become a well-established analytical technique during the last two decades. In spite of the fact that capillary electrophoresis offers a number of favorable features for high-throughput analytical assays, it is still less important than chromatographic techniques in drug development programs. Hence, the main aim of this chapter is to discuss the practical limitations of capillary electrophoresis utilization and suggest ways to overcome these constraints. This is illustrated with a practical example namely the introduction of a method allowing rapid characterization of a compound’s stability against human liver microsomes. NADP+ production monitoring was adopted to ensure generic applicability of the method. (en)
Title	Application of capillary electrophoresis for high-throughput screening of drug metabolism Application of capillary electrophoresis for high-throughput screening of drug metabolism (en)
skos:prefLabel	Application of capillary electrophoresis for high-throughput screening of drug metabolism Application of capillary electrophoresis for high-throughput screening of drug metabolism (en)
skos:notation	RIV/00216224:14310/13:00066018!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(EE2.3.20.0182), P(GAP206/10/0057), S
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Glatz, Zdeněk Řemínek, Roman
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	61693
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00066018
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Capillary electrophoresis; human liver microsomes; cytochrome P450 enzyme; drug development; metabolic stability (en)
http://linked.open.../riv/klicoveSlovo	Capillary electrophoresis cytochrome P450 enzyme human liver microsomes metabolic stability drug development
http://linked.open...ontrolniKodProRIV	[EC91E0EAFFA0]
http://linked.open...i/riv/mistoVydani	Hoboken, New Jersey
http://linked.open...vEdiceCisloSvazku	Neuveden
http://linked.open...i/riv/nazevZdroje	Capillary Electrophoresis and Microchip Capillary Electrophoresis: Principles, Applications, and Limitations
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	416 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of Multidisciplinary Research and Educational Centrum for Bioanalytical Technologies Miniaturised on-line drug-metabolism system based on capillary electrophoresis
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Glatz, Zdeněk Wang, Xu Řemínek, Roman Hoogmartens, Jos Pauwels, Jochen Van Schepdael, Ann
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/9781118530009.ch17
http://purl.org/ne...btex#hasPublisher	John Wiley & Sons, Inc.
https://schema.org/isbn	9780470572177
http://localhost/t...ganizacniJednotka	14310

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