About: Interaction of Organic Solvents with Protein Structures at Protein-Solvent Interface

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effect of non-denaturing concentrations of three different organic solvents, formamide, acetone and isopropanol, on the structure of haloalkane dehalogenases DhaA, LinB, and DbjA at the protein-solvent interface was studied using molecular dynamics simulations. Analysis of B-factors revealed that the presence of a given organic solvent mainly affects the dynamical behavior of the specificity-determining cap domain, with the exception of DbjA in acetone. Orientation of organic solvent molecules on the protein surface during the simulations was clearly dependent on their interaction with hydrophobic or hydrophilic surface patches, and the simulations suggest that the behavior of studied organic solvents in the vicinity of hyrophobic patches on the surface is similar to the air/water interface. DbjA was the only dimeric enzyme among studied haloalkane dehalogenases and provided an opportunity to explore effects of organic solvents on the quaternary structure. The effect of non-denaturing concentrations of three different organic solvents, formamide, acetone and isopropanol, on the structure of haloalkane dehalogenases DhaA, LinB, and DbjA at the protein-solvent interface was studied using molecular dynamics simulations. Analysis of B-factors revealed that the presence of a given organic solvent mainly affects the dynamical behavior of the specificity-determining cap domain, with the exception of DbjA in acetone. Orientation of organic solvent molecules on the protein surface during the simulations was clearly dependent on their interaction with hydrophobic or hydrophilic surface patches, and the simulations suggest that the behavior of studied organic solvents in the vicinity of hyrophobic patches on the surface is similar to the air/water interface. DbjA was the only dimeric enzyme among studied haloalkane dehalogenases and provided an opportunity to explore effects of organic solvents on the quaternary structure. (en)
Title	Interaction of Organic Solvents with Protein Structures at Protein-Solvent Interface Interaction of Organic Solvents with Protein Structures at Protein-Solvent Interface (en)
skos:prefLabel	Interaction of Organic Solvents with Protein Structures at Protein-Solvent Interface Interaction of Organic Solvents with Protein Structures at Protein-Solvent Interface (en)
skos:notation	RIV/00216224:14310/13:00065827!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(ED0001/01/01), P(ED1.100/02/0123), P(GA203/08/0114), P(GAP207/10/1934), P(IAA401630901), P(ME09062), S, Z(MSM6007665808)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Damborský, Jiří Brezovský, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	80648
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00065827
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	haloalkane dehalogenases (en)
http://linked.open.../riv/klicoveSlovo	haloalkane dehalogenases
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[412BF020A502]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Modeling
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	CETOCOEN Specific ion effects for proteins in solutions and related biologically relevant systems. Evolution of substrate specificity in enzymes acting on xenobiotic compounds Computer modelling study of the structure and dynamics of mineral surfaces and biomembranes and their interactions with organic and inorganic ligands Structural insight into E. coli protein WrbA, the founding member of a family of proteins implicated in defense of cells against oxidative stress St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Brezovský, Jan Damborský, Jiří Minofar, B. Khabiri, M. Ettrich, R.
http://linked.open...ain/vavai/riv/wos	000326193200010
http://linked.open...n/vavai/riv/zamer	Fyzikální biologie -nové přístupy v biologickém výzkumu
issn	1610-2940
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00894-012-1507-z
http://localhost/t...ganizacniJednotka	14310

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