About: The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

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About: The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment. The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment. (en)
Title	The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration (en)
skos:prefLabel	The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration (en)
skos:notation	RIV/00216224:14310/13:00065763!RIV14-MZ0-14310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0180), P(GAP301/11/0747), P(GAP305/11/0752), P(GD204/09/H058), P(NT11217), P(NT13493), S, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kotašková, Jana Kozubík, Alois Pospíšilová, Šárka Procházková, Jiřina Brychtová, Yvona Bryja, Vítězslav Janovská, Pavlína Doubek, Michael Mayer, Jiří Tichý, Boris Ovesná, Petra Pavlová, Šárka Verner, Jan Krejčí, Pavel Plevová, Karla Kaucká, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	96343
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00065763
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Planar cell polarity; Wnt; casein kinase 1; B-CLL (en)
http://linked.open.../riv/klicoveSlovo	casein kinase 1 Planar cell polarity B-CLL Wnt
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F4B53AF35DF9]
http://linked.open...i/riv/nazevZdroje	Cancer Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	16 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular Characterization of B-cell Receptors and Their Relationship to Evolution of Gemonic Aberrations in Chronic Lymphocytic Leukemia Cooperation between Masaryk University and Karolinska Institutet, Stockholm in the field of biomedicine The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia Intercellular signalling in development and disease Molecular mechanisms of non-canonical Wnt signaling in leukemia Molecular basis of FGFR3 signal transduction in skeletal dysplasia
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Bryja, Vítězslav Doubek, Michael Kozubík, Alois Krejčí, Pavel Mayer, Jiří Ovesná, Petra Pospíšilová, Šárka Procházková, Jiřina Verner, Jan Tichý, Boris Pavlová, Šárka Plevová, Karla Kaucká, Markéta Kotašková, Jana Janovská, Pavlína Shaik, Archana
http://linked.open...ain/vavai/riv/wos	000315741500006
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0008-5472
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1158/0008-5472.CAN-12-1752
http://localhost/t...ganizacniJednotka	14310

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