About: Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells

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About: Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug-resistance of tumor cells can be significantly modified by specific features of tumor microenvironment, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram)/Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. We show that acidic pH significantly potentiates toxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFkappaB activities and increased reactive oxygen species production. Conclusion: Specific pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ to breast and colon cancer cells. A resistance of cancer cells to chemotherapeutic agents is a major cause of treatment failure in patients with cancer. The drug-resistance of tumor cells can be significantly modified by specific features of tumor microenvironment, such as oxygen depletion (hypoxia), glucose/energy deprivation and acidosis. The effects of acidic tumor-like microenvironment on cytotoxicity of antabuse (disulfiram)/Cu2+ complexes to MCF-7 breast carcinoma and HT-29 colon carcinoma cells were studied. We show that acidic pH significantly potentiates toxicity of disulfiram/Cu2+ complex to breast and colon cancer cells. This phenomenon is associated with changes in cell metabolism, altered Akt kinase and NFkappaB activities and increased reactive oxygen species production. Conclusion: Specific pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ to breast and colon cancer cells. (en)
Title	Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells (en)
skos:prefLabel	Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells Acidic pH of tumor microenvironment enhances cytotoxicity of disulfiram/Cu2+ complex to breast and colon cancer cells (en)
skos:notation	RIV/00216224:14310/13:00065625!RIV14-MZ0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/09/1115), P(NT13441)
http://linked.open...iv/cisloPeriodika	59
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Navrátilová, Jarmila Hankeová, Tereza Beneš, Petr Šmarda, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	59341
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00065625
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Breast cancer; Colon cancer; Cytotoxicity; Disulfiram; Reactive Oxygen Species; Tumor microenvironment (en)
http://linked.open.../riv/klicoveSlovo	Disulfiram Reactive Oxygen Species Tumor microenvironment Breast cancer Cytotoxicity Colon cancer
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[1811B3413E22]
http://linked.open...i/riv/nazevZdroje	CHEMOTHERAPY
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of c-Myb and Cox-2 proteins in colon carcinogenesis Myb Protein Family Expression in Colorectal Adenocarcinoma and its Correlation to Metastatic Potential
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	2013
http://linked.open...iv/tvurceVysledku	Beneš, Petr Šmarda, Jan Hankeová, Tereza Navrátilová, Jarmila
http://linked.open...ain/vavai/riv/wos	000325833000006
issn	0009-3157
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000353915
http://localhost/t...ganizacniJednotka	14310

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