About: Pro- and anti-tumor effects of wedelolactone in breast cancer cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Pro- and anti-tumor effects of wedelolactone in breast cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Natural phytocompounds and their derivatives are commonly used for prevention and treatment of various diseases, including cancer. Wedelolactone is one of the active polyphenolic compounds in extracts of Wedelia calandulaceae and Eclipta prostrata. Wedelolactone was shown to inhibit growth of breast and prostate cancer cells in vitro and in vivo. The growth inhibitory effects of wedelolactone have been largely attributed to the inhibition of IKK kinase, the key enzyme regulating the activity of NFkB. We have recently described that wedelolactone inhibits DNA synthesis and acts as catalytic inhibitor of DNA topoisomerase IIalpha. This study was designed to characterize the mechanisms of wedelolactone effects on breast cancer cells in detail. We observed that in nM concentrations, wedelolactone stimulates growth of ER-positive breast cancer cells MCF-7 and T47D by activation of genomic ER-signalling pathway. This growth-stimulatory effect was not detected in ER-negative MDA-MB-231 breast cancer cells. Natural phytocompounds and their derivatives are commonly used for prevention and treatment of various diseases, including cancer. Wedelolactone is one of the active polyphenolic compounds in extracts of Wedelia calandulaceae and Eclipta prostrata. Wedelolactone was shown to inhibit growth of breast and prostate cancer cells in vitro and in vivo. The growth inhibitory effects of wedelolactone have been largely attributed to the inhibition of IKK kinase, the key enzyme regulating the activity of NFkB. We have recently described that wedelolactone inhibits DNA synthesis and acts as catalytic inhibitor of DNA topoisomerase IIalpha. This study was designed to characterize the mechanisms of wedelolactone effects on breast cancer cells in detail. We observed that in nM concentrations, wedelolactone stimulates growth of ER-positive breast cancer cells MCF-7 and T47D by activation of genomic ER-signalling pathway. This growth-stimulatory effect was not detected in ER-negative MDA-MB-231 breast cancer cells. (en)
Title	Pro- and anti-tumor effects of wedelolactone in breast cancer cells Pro- and anti-tumor effects of wedelolactone in breast cancer cells (en)
skos:prefLabel	Pro- and anti-tumor effects of wedelolactone in breast cancer cells Pro- and anti-tumor effects of wedelolactone in breast cancer cells (en)
skos:notation	RIV/00216224:14310/13:00065616!RIV14-MZ0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13441)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Nehybová, Tereza Beneš, Petr Šmarda, Jan
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	99636
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00065616
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	breast cancer; wedelolactone; phytoestrogen; apoptosis; cell signalling (en)
http://linked.open.../riv/klicoveSlovo	phytoestrogen breast cancer apoptosis wedelolactone cell signalling
http://linked.open...ontrolniKodProRIV	[31AF1C2E782E]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Myb Protein Family Expression in Colorectal Adenocarcinoma and its Correlation to Metastatic Potential
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Beneš, Petr Šmarda, Jan Nehybová, Tereza
http://localhost/t...ganizacniJednotka	14310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software