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rdf:type
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Description
| - Growth of tumor cells depends on sufficient supply of fermentable substrate, such as glucose. This provokes development of new anti-cancer therapies based on dietary restrictions. However, some tumor cells can lower their glucose dependency and activate processes of ATP formation/saving to retain viability even in limited glucose supply. In addition, tumor cells often loose sensitivity to many conventional anti-cancer drugs in the low-glucose conditions. Thus, development of the drugs effectively killing the tumor cells in nutrient-limited conditions is necessary. In this study, we show an enhanced cytotoxicity of tetrathiomolybdate, the drug exhibiting anti-angiogenic and tumor-suppressing effects, to neuroblastoma SH-SY5Y and SK-N-BE(2) cells in the low-glucose conditions. This preference results from the tetrathiomolybdate-induced upregulation of cell dependency on glucose.
- Growth of tumor cells depends on sufficient supply of fermentable substrate, such as glucose. This provokes development of new anti-cancer therapies based on dietary restrictions. However, some tumor cells can lower their glucose dependency and activate processes of ATP formation/saving to retain viability even in limited glucose supply. In addition, tumor cells often loose sensitivity to many conventional anti-cancer drugs in the low-glucose conditions. Thus, development of the drugs effectively killing the tumor cells in nutrient-limited conditions is necessary. In this study, we show an enhanced cytotoxicity of tetrathiomolybdate, the drug exhibiting anti-angiogenic and tumor-suppressing effects, to neuroblastoma SH-SY5Y and SK-N-BE(2) cells in the low-glucose conditions. This preference results from the tetrathiomolybdate-induced upregulation of cell dependency on glucose. (en)
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Title
| - Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells
- Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells (en)
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skos:prefLabel
| - Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells
- Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells (en)
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skos:notation
| - RIV/00216224:14310/13:00065615!RIV14-MZ0-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(ED1.100/02/0123), P(GA301/09/1115), P(NT13441)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/13:00065615
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - tetrathiomolybdate; neuroblastoma; glucose starvation; apoptosis; cancer therapy (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Beneš, Petr
- Šmarda, Jan
- Hankeová, Tereza
- Navrátilová, Jarmila
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1080/01635581.2013.789118
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http://localhost/t...ganizacniJednotka
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