About: Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Deregulation of c-Myb occurs frequently in breast cancer and other malignancies. We described that the Myb overexpression in breast carcinoma cell lines can differentially affect cell migration and invasion in vitro depending on chemotaktic/chemokinetic conditions and matrix composition. The Myb-overexpressing mammary tumors in syngeneic BALB/C model rarely metastasized to lungs in contrast to control tumors, though the formation of the bone and liver metastases was not affected. The selective disdavantage of these cells in lung colonization might result frem their inability to penetrate a vessel wall and underlying basement membrane in lung parenchyma. We targeted the specific aspects of tumor-endothelial cell intractions and demonstrated the capacity of transendothelial migration of the Myb-overexpressing MDA-MB-231 cells was impaired. Deregulation of c-Myb occurs frequently in breast cancer and other malignancies. We described that the Myb overexpression in breast carcinoma cell lines can differentially affect cell migration and invasion in vitro depending on chemotaktic/chemokinetic conditions and matrix composition. The Myb-overexpressing mammary tumors in syngeneic BALB/C model rarely metastasized to lungs in contrast to control tumors, though the formation of the bone and liver metastases was not affected. The selective disdavantage of these cells in lung colonization might result frem their inability to penetrate a vessel wall and underlying basement membrane in lung parenchyma. We targeted the specific aspects of tumor-endothelial cell intractions and demonstrated the capacity of transendothelial migration of the Myb-overexpressing MDA-MB-231 cells was impaired. (en)
Title	Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions (en)
skos:prefLabel	Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions Microenvironment-dependent function of c-Myb in breast cancer: the focus on the tumor-endothelial cell interactions (en)
skos:notation	RIV/00216224:14310/13:00065599!RIV14-MZ0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13441)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Beneš, Petr Šmarda, Jan Knopfová, Lucia
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	88165
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00065599
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	c-Myb; breast tumor; tumor microenvironment; invasivity (en)
http://linked.open.../riv/klicoveSlovo	invasivity c-Myb tumor microenvironment breast tumor
http://linked.open...ontrolniKodProRIV	[CB78F19CA573]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Myb Protein Family Expression in Colorectal Adenocarcinoma and its Correlation to Metastatic Potential
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Beneš, Petr Hermanová, Markéta Knopfová, Lucia Masařík, Michal Šmarda, Jan
http://localhost/t...ganizacniJednotka	14310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 75 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software