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  • Cisplatin is highly effective in treating a variety of cancers [ 1] but both inherited and acquired tumoral cell resistance seriously limits its applications [2]. Anticancer drugs are widely used in suitable combinations in order to improve their action [3]. In the cell, associations of two or more drugs may exhibit synergistic, antagonistic or addictive effects. Synergistic, antagonistic or additive type of interaction occurs when the cytotoxicity of the drug combination is respectively greater, lower, or equal to the sum of the cytotoxicity of individual drugs. Complexes of copper(II) with 1,10-ortho-phenanthroline (phen) are also endowed with cytotoxic and antitumoral effects being capable of cleaving DNA and improving nuclease activity [4].
  • Cisplatin is highly effective in treating a variety of cancers [ 1] but both inherited and acquired tumoral cell resistance seriously limits its applications [2]. Anticancer drugs are widely used in suitable combinations in order to improve their action [3]. In the cell, associations of two or more drugs may exhibit synergistic, antagonistic or addictive effects. Synergistic, antagonistic or additive type of interaction occurs when the cytotoxicity of the drug combination is respectively greater, lower, or equal to the sum of the cytotoxicity of individual drugs. Complexes of copper(II) with 1,10-ortho-phenanthroline (phen) are also endowed with cytotoxic and antitumoral effects being capable of cleaving DNA and improving nuclease activity [4]. (en)
Title
  • Synergistic cytotoxicity of copper(II) complexes in combination with cisplatin: an application of artificial neural networks and experimental design
  • Synergistic cytotoxicity of copper(II) complexes in combination with cisplatin: an application of artificial neural networks and experimental design (en)
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  • Synergistic cytotoxicity of copper(II) complexes in combination with cisplatin: an application of artificial neural networks and experimental design
  • Synergistic cytotoxicity of copper(II) complexes in combination with cisplatin: an application of artificial neural networks and experimental design (en)
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  • RIV/00216224:14310/12:00078233!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita
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  • Z(MSM0021622411)
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  • Amato, Filippo
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  • RIV/00216224:14310/12:00078233
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  • artificial neural networks; synergism; experimental design (en)
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  • [04AB01F5788C]
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  • Amato, Filippo
  • Pivetta, Tiziana
  • Manca, Matteo
  • Perra, Daniela
  • Trudu, Federica
  • Isaia, Franco
  • Spiga, Francesca
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  • 14310
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