About: Caspase 3 chemiluminescence activity determination in apoptotic cells and design of caspase-3 sensor

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About: Caspase 3 chemiluminescence activity determination in apoptotic cells and design of caspase-3 sensor Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development of tumor or autoimmune disorders. In some instances knowledges of this pathway can be used for inhibit or prevent cancer development and other diseases. One of the earliest and most consistent observed features of apoptosis is the induction of a series of cytosolic proteases - caspases. Active caspases cleave numerous intracellular proteins and contribute to apoptotic cell death. Caspases recognize tetra-peptide sequences Asp-Glu-Val-Asp on their substrates and hydrolyze peptide bonds after aspartic acid residues. It is known from literature that in one apoptotic cell about 1.6x10(-19) mol of caspase can be activated. Various techniques for the determination of caspase 3 in free cells or tissue samples are commercially available. Caspase 3 activity is usually assayed by a chemiluminescence reaction. The best commercial methods reach the limit o detection higher than 1 pg of caspase 3. Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development of tumor or autoimmune disorders. In some instances knowledges of this pathway can be used for inhibit or prevent cancer development and other diseases. One of the earliest and most consistent observed features of apoptosis is the induction of a series of cytosolic proteases - caspases. Active caspases cleave numerous intracellular proteins and contribute to apoptotic cell death. Caspases recognize tetra-peptide sequences Asp-Glu-Val-Asp on their substrates and hydrolyze peptide bonds after aspartic acid residues. It is known from literature that in one apoptotic cell about 1.6x10(-19) mol of caspase can be activated. Various techniques for the determination of caspase 3 in free cells or tissue samples are commercially available. Caspase 3 activity is usually assayed by a chemiluminescence reaction. The best commercial methods reach the limit o detection higher than 1 pg of caspase 3. (en)
Title	Caspase 3 chemiluminescence activity determination in apoptotic cells and design of caspase-3 sensor Caspase 3 chemiluminescence activity determination in apoptotic cells and design of caspase-3 sensor (en)
skos:prefLabel	Caspase 3 chemiluminescence activity determination in apoptotic cells and design of caspase-3 sensor Caspase 3 chemiluminescence activity determination in apoptotic cells and design of caspase-3 sensor (en)
skos:notation	RIV/00216224:14310/12:00072525!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Lišková, Marcela Foret, František Klepárník, Karel Pazdera, Pavel
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	126097
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00072525
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Apoptosis; Caspases; Chemiluminiscence (en)
http://linked.open.../riv/klicoveSlovo	Caspases Chemiluminiscence Apoptosis
http://linked.open...ontrolniKodProRIV	[43CE1E648071]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Foret, František Klepárník, Karel Lišková, Marcela Pazdera, Pavel
http://localhost/t...ganizacniJednotka	14310

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