About: Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

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About: Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6. Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6. (en)
Title	Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation (en)
skos:prefLabel	Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation (en)
skos:notation	RIV/00216224:14310/12:00067402!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kozubík, Alois Procházková, Jiřina Bryja, Vítězslav Veselá, Iva Krejčí, Pavel Kaucká, Markéta Mikolka, Pavol Spoustová, Tereza Pospíšilová, Tereza Ševčíková, Eva Bálek, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	164373
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00067402
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Receptor tyrosin kinase; Wnt/beta catenin; MAPK; LRP6 (en)
http://linked.open.../riv/klicoveSlovo	MAPK Receptor tyrosin kinase Wnt/beta catenin LRP6
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BABE603183E4]
http://linked.open...i/riv/nazevZdroje	Plos One
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	20 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Kozubík, Alois Krejčí, Pavel Procházková, Jiřina Veselá, Iva Pospíšilová, Tereza Kaucká, Markéta Mikolka, Pavol Aklian, Anie Bálek, Lukáš Gutkind, J. S. Mašek, Jan Kukla Paznekas, W. A. Salazar, Lisa Spoustová, Tereza Weis, MaryAnn Wilcox, W. A. Wnag Jabs, E. Wolf, J. H. Ševčíková, Eva
http://linked.open...ain/vavai/riv/wos	000305336000063
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1932-6203
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0035826
http://localhost/t...ganizacniJednotka	14310

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