About: Analysis of estrogenicity, toxicity and neurotoxicity of Microcystis aerigunosa, Cylidrospermopsis raciborskii and Scenedesmus quadricauda exudates with zebrafish (Danio rerio) embryos.

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About: Analysis of estrogenicity, toxicity and neurotoxicity of Microcystis aerigunosa, Cylidrospermopsis raciborskii and Scenedesmus quadricauda exudates with zebrafish (Danio rerio) embryos. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cyanobacteria are known to synthesize mixture of diverse biologically active compounds which are partially excreted into natural water bodies. The structural identity as well as potential biological activity and toxicological properties of many of these compounds are still unknown. In this study the zebrafish embryo model was used to investigate the potential estrogenicity, neurotoxicity and general toxicity of exudates from laboratory cultures of two cyanobacteria species Microcystis aerigunosa and Cylidrospermopsis raciborskii and one green algae Scenedesmus quadricauda. Exudate samples were collected after 21-day exponential growth separating the liquid phase from cells; after that the liquid phase was extracted by solid phase extraction. A transgenic zebrafish strain (cyp19a1b-GFP, Brion et al., PloS ONE 2012, e36069) was used to assess the estrogenicity. This strain expresses green fluorescent protein under the control of aromatase B (cyp19a1b) promoter, which is induced by estrogens. Cyanobacteria are known to synthesize mixture of diverse biologically active compounds which are partially excreted into natural water bodies. The structural identity as well as potential biological activity and toxicological properties of many of these compounds are still unknown. In this study the zebrafish embryo model was used to investigate the potential estrogenicity, neurotoxicity and general toxicity of exudates from laboratory cultures of two cyanobacteria species Microcystis aerigunosa and Cylidrospermopsis raciborskii and one green algae Scenedesmus quadricauda. Exudate samples were collected after 21-day exponential growth separating the liquid phase from cells; after that the liquid phase was extracted by solid phase extraction. A transgenic zebrafish strain (cyp19a1b-GFP, Brion et al., PloS ONE 2012, e36069) was used to assess the estrogenicity. This strain expresses green fluorescent protein under the control of aromatase B (cyp19a1b) promoter, which is induced by estrogens. (en)
Title	Analysis of estrogenicity, toxicity and neurotoxicity of Microcystis aerigunosa, Cylidrospermopsis raciborskii and Scenedesmus quadricauda exudates with zebrafish (Danio rerio) embryos. Analysis of estrogenicity, toxicity and neurotoxicity of Microcystis aerigunosa, Cylidrospermopsis raciborskii and Scenedesmus quadricauda exudates with zebrafish (Danio rerio) embryos. (en)
skos:prefLabel	Analysis of estrogenicity, toxicity and neurotoxicity of Microcystis aerigunosa, Cylidrospermopsis raciborskii and Scenedesmus quadricauda exudates with zebrafish (Danio rerio) embryos. Analysis of estrogenicity, toxicity and neurotoxicity of Microcystis aerigunosa, Cylidrospermopsis raciborskii and Scenedesmus quadricauda exudates with zebrafish (Danio rerio) embryos. (en)
skos:notation	RIV/00216224:14310/12:00067013!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED0001/01/01), P(GAP503/12/0553), S
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Jonáš, Adam Nováková, Kateřina Hilscherová, Klára
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	122126
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00067013
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyanobacteria; Estrogenic activity; Zebrafish embryo model (en)
http://linked.open.../riv/klicoveSlovo	Estrogenic activity Zebrafish embryo model Cyanobacteria
http://linked.open...ontrolniKodProRIV	[7A8731450905]
http://linked.open...in/vavai/riv/obor	DJ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Endocrine disruptive potential of cyanobacterial metabolites CETOCOEN
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Hilscherová, Klára Nováková, Kateřina Jonáš, Adam Fetter, Eva Ortmann, Julia Scholz, Stefan
http://localhost/t...ganizacniJednotka	14310

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