About: Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53     Goto   Sponge   NotDistinct   Permalink

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  • Roscovitine, an inhibitor of cyclin-dependent kinases, is promising anticancer agent. Its antiproliferative and cytotoxic effects can be mediated by the p53 signaling pathway. To define the role of p53 in roscovitine-induced cell response, we prepared H1299/p53 cell lines inducibly expressing specific variants of p53 (p53wt and hotspot R175H, temperature-dependent P98A, A159V, S215G, Y220C, Y234C mutants). In the presence of roscovitine, each cell line variant behaved in specific way reflecting activity of the p53 protein. Roscovitine decreased production of the cell cycle inhibitor p21 and induced apoptosis. This effect was the most efficient in cells expressing p53wt protein with full activity. The cell expressing partially and conditionally active p53 mutants responded to roscovitine less efficiently. The cells expressing p53 mutants A159V and Y234C were very sensitive to roscovitine but their response was clearly temperature-dependent.
  • Roscovitine, an inhibitor of cyclin-dependent kinases, is promising anticancer agent. Its antiproliferative and cytotoxic effects can be mediated by the p53 signaling pathway. To define the role of p53 in roscovitine-induced cell response, we prepared H1299/p53 cell lines inducibly expressing specific variants of p53 (p53wt and hotspot R175H, temperature-dependent P98A, A159V, S215G, Y220C, Y234C mutants). In the presence of roscovitine, each cell line variant behaved in specific way reflecting activity of the p53 protein. Roscovitine decreased production of the cell cycle inhibitor p21 and induced apoptosis. This effect was the most efficient in cells expressing p53wt protein with full activity. The cell expressing partially and conditionally active p53 mutants responded to roscovitine less efficiently. The cells expressing p53 mutants A159V and Y234C were very sensitive to roscovitine but their response was clearly temperature-dependent. (en)
Title
  • Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53
  • Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53 (en)
skos:prefLabel
  • Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53
  • Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53 (en)
skos:notation
  • RIV/00216224:14310/12:00064886!RIV13-MZ0-14310___
http://linked.open...avai/riv/aktivita
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  • P(NS10448)
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  • 6
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  • 166176
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  • RIV/00216224:14310/12:00064886
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  • roscovitine; apoptosis; p53 temperature-dependent mutants; H1299 cells (en)
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  • SK - Slovenská republika
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  • [77C43D2DCD11]
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  • 59
http://linked.open...iv/tvurceVysledku
  • Šmarda, Jan
  • Šmardová, Jana
  • Slováčková, Jana
http://linked.open...ain/vavai/riv/wos
  • 000310820200002
issn
  • 0028-2685
number of pages
http://bibframe.org/vocab/doi
  • 10.4149/neo_2012_077
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  • 14310
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