About: Characterization of Protein Glycosylation in Francisella tularensis subsp. holarctica

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About: Characterization of Protein Glycosylation in Francisella tularensis subsp. holarctica Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	: FTH_0069 is a previously uncharacterized strongly immunoreactive protein that has been proposed to be a novel virulence factor in Francisella tularensis. Here, the glycan structure modifying two C-terminal peptides of FTH_0069 was identified utilizing high resolution, high mass accuracy mass spectrometry, combined with in-source CID tandem MS experiments. The glycan observed at m/z 1156 was determined to be a hexasaccharide, consisting of two hexoses, three N-acetylhexosamines, and an unknown monosaccharide containing a phosphate group. The monosaccharide sequence of the glycan is tentatively proposed as X-P-HexNAc-HexNAc-Hex-Hex-HexNAc, where X denotes the unknown monosaccharide. The glycan is identical to that of DsbA glycoprotein, as well as to one of the multiple glycan structures modifying the type IV pilin PilA, suggesting a common biosynthetic pathway for the protein modification. : FTH_0069 is a previously uncharacterized strongly immunoreactive protein that has been proposed to be a novel virulence factor in Francisella tularensis. Here, the glycan structure modifying two C-terminal peptides of FTH_0069 was identified utilizing high resolution, high mass accuracy mass spectrometry, combined with in-source CID tandem MS experiments. The glycan observed at m/z 1156 was determined to be a hexasaccharide, consisting of two hexoses, three N-acetylhexosamines, and an unknown monosaccharide containing a phosphate group. The monosaccharide sequence of the glycan is tentatively proposed as X-P-HexNAc-HexNAc-Hex-Hex-HexNAc, where X denotes the unknown monosaccharide. The glycan is identical to that of DsbA glycoprotein, as well as to one of the multiple glycan structures modifying the type IV pilin PilA, suggesting a common biosynthetic pathway for the protein modification. (en)
Title	Characterization of Protein Glycosylation in Francisella tularensis subsp. holarctica Characterization of Protein Glycosylation in Francisella tularensis subsp. holarctica (en)
skos:prefLabel	Characterization of Protein Glycosylation in Francisella tularensis subsp. holarctica Characterization of Protein Glycosylation in Francisella tularensis subsp. holarctica (en)
skos:notation	RIV/00216224:14310/12:00062587!RIV13-MSM-14310___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA203/09/0857), P(ME08105), P(NS9747), Z(MO0FVZ0000604)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Chovancová, Eva Damborský, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	126832
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00062587
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Francisella tularensis; glycosylation; FTH_0069; DsbA; PilA; O-antigen; mass spectrometry (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry Francisella tularensis DsbA FTH_0069 O-antigen PilA glycosylation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[84C8117FF1DB]
http://linked.open...i/riv/nazevZdroje	Molecular and Cellurar Proteomic
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Differential proteome analysis of bacterial Francisella tularensis glyco- and phospho- proteins Development of novel tularemic vaccine based on determination of molecular principle of tularemic pathogenesis New analytical approaches for identification of proteins with significant attributes for virulence and pathogenity of bacteria
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Balonová, Lucie Damborský, Jiří Stulík, Jiří Červený, Lukáš Šebestová, Eva Alley, W.R.Jr Forsbeg, A. Forslund, Anna-Lena Henrychová, Lenka Mann, B. F. Novotný, L. V. Solomonsson, E. N.
http://linked.open...ain/vavai/riv/wos	000306411300004
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	1535-9476
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/mcp.M111.015016
http://localhost/t...ganizacniJednotka	14310

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