About: Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells     Goto   Sponge   NotDistinct   Permalink

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  • The p53 protein is a sequence-specific transcription factor controlling the expression of multiple genes and protecting cells from oncogenic transformation. In many tumors, the p53 protein is completely or partially inactivated by mutations in the p53 gene. We analyzed the transactivating activity of nine human temperature-dependent (td) p53 mutants in yeast cells. Mutations in seven of them were localized in the beta-sandwich-coding region of the p53 gene, eight p53 mutants were temperature-sensitive and the R283C mutant was coldsensitive. Patterns of their transactivation abilities towards three different responsive elements, the extent of their temperature dependency as well as discriminativity, were considerably variable. Similarly, their capacity to become reactivated by amifostine varied from complete resistance to high sensitivity.
  • The p53 protein is a sequence-specific transcription factor controlling the expression of multiple genes and protecting cells from oncogenic transformation. In many tumors, the p53 protein is completely or partially inactivated by mutations in the p53 gene. We analyzed the transactivating activity of nine human temperature-dependent (td) p53 mutants in yeast cells. Mutations in seven of them were localized in the beta-sandwich-coding region of the p53 gene, eight p53 mutants were temperature-sensitive and the R283C mutant was coldsensitive. Patterns of their transactivation abilities towards three different responsive elements, the extent of their temperature dependency as well as discriminativity, were considerably variable. Similarly, their capacity to become reactivated by amifostine varied from complete resistance to high sensitivity. (en)
Title
  • Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells
  • Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells (en)
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  • Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells
  • Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells (en)
skos:notation
  • RIV/00216224:14310/12:00060467!RIV13-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NS10448), S, V
http://linked.open...iv/cisloPeriodika
  • 3
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  • 174840
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  • RIV/00216224:14310/12:00060467
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  • p53; transactivation; temperature-dependent p53 mutants; discriminating p53 mutants; functional analysis of separated alleles in yeast (en)
http://linked.open.../riv/klicoveSlovo
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  • GR - Řecká republika
http://linked.open...ontrolniKodProRIV
  • [B4874F0AA4C8]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Oncology
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  • 41
http://linked.open...iv/tvurceVysledku
  • Ravčuková, Barbora
  • Šmarda, Jan
  • Šmardová, Jana
  • Slováčková, Jana
  • Jagošová, Jana
  • Pitrová, Lenka
http://linked.open...ain/vavai/riv/wos
  • 000307150000042
issn
  • 1019-6439
number of pages
http://bibframe.org/vocab/doi
  • 10.3892/ijo.2012.1520
http://localhost/t...ganizacniJednotka
  • 14310
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