About: Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies

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About: Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.linkos.cz/casopis-klinicka-onkologie/hledani-clanku/skupina/a/zobrazit/ids/4135/
Description	Background: Cancer metastasis involves changes in signalling pathways, cell adhesion, migration and invasiveness. Modern proteomic, mass spectrometry based techniques enable discovery of new pro-metastatic proteins and their functional partners. Also, they might be involved in their functional characterization and validation towards development of new diagnostic and therapeutic approaches. Aim: The aim of this communication is to describe current possibilities for proteomic techniques in the discovery and characterization of pro-metastatic targets. The NF-kappaB pathway is one of the players responsible for a number of pro-metastatic processes. The related proteins can be discovered using untargeted proteomic approaches by comparing proteomes with different metastatic potential. Stable isotope labelling based methods enable a parallel analysis of more tumour samples. Background: Cancer metastasis involves changes in signalling pathways, cell adhesion, migration and invasiveness. Modern proteomic, mass spectrometry based techniques enable discovery of new pro-metastatic proteins and their functional partners. Also, they might be involved in their functional characterization and validation towards development of new diagnostic and therapeutic approaches. Aim: The aim of this communication is to describe current possibilities for proteomic techniques in the discovery and characterization of pro-metastatic targets. The NF-kappaB pathway is one of the players responsible for a number of pro-metastatic processes. The related proteins can be discovered using untargeted proteomic approaches by comparing proteomes with different metastatic potential. Stable isotope labelling based methods enable a parallel analysis of more tumour samples. (en)
Title	Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies (en)
skos:prefLabel	Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies Identification and characterization of pro-metastatic targets, pathways and molecular complexes using a toolbox of proteomic technologies (en)
skos:notation	RIV/00216224:14310/12:00058654!RIV13-GA0-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GAP304/10/0868), S
http://linked.open...iv/cisloPeriodika	Suppl. 2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Struhárová, Iva Bouchal, Pavel Dvořáková, Monika Faktor, Jakub Maryáš, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	140260
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00058654
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metastázy; proteomika; tumorové markery; buněčná migrace; membránové proteiny; přenos signálů; hmotnostní spektrometrie; izotopové značení (en)
http://linked.open.../riv/klicoveSlovo	buněčná migrace hmotnostní spektrometrie izotopové značení membránové proteiny metastázy přenos signálů proteomika tumorové markery
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2F2E4B8E3345]
http://linked.open...i/riv/nazevZdroje	Klinická onkologie
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The proteomics-based study on molecular mechanisms of early lymph node metastases formation in low-grade breast cancer
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Bouchal, Pavel Struhárová, Iva Dvořáková, Monika Faktor, Jakub Maryáš, Josef
issn	0862-495X
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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