About: Application of On-line Capillary Electrophoresis Coupled to Mass Spectrometry for Identification of Cytochrome P450 2C9 Isoform Metabolism Products

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Drug biotransformation mediated by cytochrome P450 enzymes (CYP) is a pivotal factor in the early developmental stages of new drugs. Metabolism appraisal of every hit thus constitutes the inseparable part of ADME/tox screenings. Capillary electrophoresis (CE) represents a promising technique in the field of enzyme assays due to miniscule sample consumption and high-throughput by automation. Moreover, CE coupled to mass spectrometry (MS) combines the advantages of both techniques so that CYP metabolism products can be identified on the bases of migration time, molecular weight and fragmentation. A new CE-MS method enabling identification of reaction products provided by clinically important CYP2C9 isoform is thus introduced. Drug biotransformation mediated by cytochrome P450 enzymes (CYP) is a pivotal factor in the early developmental stages of new drugs. Metabolism appraisal of every hit thus constitutes the inseparable part of ADME/tox screenings. Capillary electrophoresis (CE) represents a promising technique in the field of enzyme assays due to miniscule sample consumption and high-throughput by automation. Moreover, CE coupled to mass spectrometry (MS) combines the advantages of both techniques so that CYP metabolism products can be identified on the bases of migration time, molecular weight and fragmentation. A new CE-MS method enabling identification of reaction products provided by clinically important CYP2C9 isoform is thus introduced. (en)
Title	Application of On-line Capillary Electrophoresis Coupled to Mass Spectrometry for Identification of Cytochrome P450 2C9 Isoform Metabolism Products Application of On-line Capillary Electrophoresis Coupled to Mass Spectrometry for Identification of Cytochrome P450 2C9 Isoform Metabolism Products (en)
skos:prefLabel	Application of On-line Capillary Electrophoresis Coupled to Mass Spectrometry for Identification of Cytochrome P450 2C9 Isoform Metabolism Products Application of On-line Capillary Electrophoresis Coupled to Mass Spectrometry for Identification of Cytochrome P450 2C9 Isoform Metabolism Products (en)
skos:notation	RIV/00216224:14310/12:00057805!RIV13-GA0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP206/10/0057), P(GBP206/12/G014)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Glatz, Zdeněk Zeisbergerová, Marta Langmajerová, Monika Řemínek, Roman
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	123361
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00057805
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	On-line capillary electrophoresis; mass spectrometry; enzyme reaction (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry On-line capillary electrophoresis enzyme reaction
http://linked.open...ontrolniKodProRIV	[E4BBFB693385]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	9th International Interdisciplinary Meeting on Bioanalysis, CECE 2012
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for advanced bioanalytical technologies Miniaturised on-line drug-metabolism system based on capillary electrophoresis
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Glatz, Zdeněk Langmajerová, Monika Zeisbergerová, Marta Řemínek, Roman
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2012-11-01 (xsd:date)
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	IACH AV ČR Brno
https://schema.org/isbn	9788090495913
http://localhost/t...ganizacniJednotka	14310

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