About: Structural insight into binding variability of Aspergillus fumigatus lectin

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have identified one lectin that is present on conidia surface of A. fumigatus and thus can be involved in host tissue binding. The binding experiments clearly showed presence of more than one type of binding sites. By preparing protein crystals and solving the 3D structure by X-ray diffraction, we were able to identify six binding sites per monomer. The more complex analysis of structures with different ligands distinguished different binding pattern of each binding site that results in variable specificity and can be correlated with other experimental data. We have identified one lectin that is present on conidia surface of A. fumigatus and thus can be involved in host tissue binding. The binding experiments clearly showed presence of more than one type of binding sites. By preparing protein crystals and solving the 3D structure by X-ray diffraction, we were able to identify six binding sites per monomer. The more complex analysis of structures with different ligands distinguished different binding pattern of each binding site that results in variable specificity and can be correlated with other experimental data. (en)
Title	Structural insight into binding variability of Aspergillus fumigatus lectin Structural insight into binding variability of Aspergillus fumigatus lectin (en)
skos:prefLabel	Structural insight into binding variability of Aspergillus fumigatus lectin Structural insight into binding variability of Aspergillus fumigatus lectin (en)
skos:notation	RIV/00216224:14310/12:00057542!RIV13-GA0-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GA303/09/1168), S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Komárek, Jan Houser, Josef Kostlánová, Nikola Wimmerová, Michaela
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	171828
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00057542
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lectin; aspergillus; protein structure (en)
http://linked.open.../riv/klicoveSlovo	lectin protein structure aspergillus
http://linked.open...ontrolniKodProRIV	[5A6C65E22F9F]
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Lectins from human pathogens - structure, function, engineering
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Cioci, Gianluca Houser, Josef Imberty, Anne Komárek, Jan Kostlánová, Nikola Wimmerová, Michaela
http://localhost/t...ganizacniJednotka	14310

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