About: Aspergillus fumigatus lectin - a model system for the study of multivalent lectins

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About: Aspergillus fumigatus lectin - a model system for the study of multivalent lectins Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lectins are sugar-specific proteins involved in recognition events in a variety of physiological and pathological processes. The project is focused on a detailed characterization of L-fucose specific lectin AFL from ascomycete Aspergillus fumigatus. Structure-function studies of AFL revealed presence of six binding sites with different affinities and specificities towards fucosylated oligosaccharides. Detailed knowledge of differences in binding properties of individual AFL binding sites would be important in understanding the basis of protein-carbohydrate recognition. Further study is therefore needed to examine the fine details in behaviour of different AFL binding sites. This study uses a novel approach which is based on a synthetic gene and site-directed mutagenesis. The procedure should result in preparation of six monovalent forms of AFL (corresponding to individual binding sites) and their characterization from structure-function point of view. Lectins are sugar-specific proteins involved in recognition events in a variety of physiological and pathological processes. The project is focused on a detailed characterization of L-fucose specific lectin AFL from ascomycete Aspergillus fumigatus. Structure-function studies of AFL revealed presence of six binding sites with different affinities and specificities towards fucosylated oligosaccharides. Detailed knowledge of differences in binding properties of individual AFL binding sites would be important in understanding the basis of protein-carbohydrate recognition. Further study is therefore needed to examine the fine details in behaviour of different AFL binding sites. This study uses a novel approach which is based on a synthetic gene and site-directed mutagenesis. The procedure should result in preparation of six monovalent forms of AFL (corresponding to individual binding sites) and their characterization from structure-function point of view. (en)
Title	Aspergillus fumigatus lectin - a model system for the study of multivalent lectins Aspergillus fumigatus lectin - a model system for the study of multivalent lectins (en)
skos:prefLabel	Aspergillus fumigatus lectin - a model system for the study of multivalent lectins Aspergillus fumigatus lectin - a model system for the study of multivalent lectins (en)
skos:notation	RIV/00216224:14310/12:00057369!RIV13-GA0-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GD301/09/H004), S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Wimmerová, Michaela
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	123787
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00057369
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Aspergillus fumigatus; lectins (en)
http://linked.open.../riv/klicoveSlovo	Aspergillus fumigatus lectins
http://linked.open...ontrolniKodProRIV	[AA400B3EB5D7]
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Houser, Josef Imberty, Anne Komárek, Jan Kostlánová, Nikola Pokorná, Marie Wimmerová, Michaela
http://localhost/t...ganizacniJednotka	14310

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