About: Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways

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About: Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recently, it is suggested that some dietary polyunsaturated fatty acids (PUFAs) play an important role in suppression of colon cancer. Namely n-3 PUFAs, such as docosahexaenoic acid (DHA), showed antiproliferative and apoptotic effects in colon cancer cells. However, DHA is preferentially considered as supporting agent in combined anticancer therapy. TNF-related Apoptosis Inducing Ligand (TRAIL) is cytokine able to induce apoptosis in cancer cells with little effect on normal cells. It is promising for cancer treatment, but some cancer cells appeared to be resistant to TRAIL-induced apoptosis. We showed that pretreatment with physiological doses of DHA results in significantly enhanced TRAIL-induced apoptosis of otherwise resistant human colon cells as documented by increased caspase activation and cleavage of their substrates. We demonstrated activation of crucial mitochondrial proapototic molecules, such as Bax and Bak. Recently, it is suggested that some dietary polyunsaturated fatty acids (PUFAs) play an important role in suppression of colon cancer. Namely n-3 PUFAs, such as docosahexaenoic acid (DHA), showed antiproliferative and apoptotic effects in colon cancer cells. However, DHA is preferentially considered as supporting agent in combined anticancer therapy. TNF-related Apoptosis Inducing Ligand (TRAIL) is cytokine able to induce apoptosis in cancer cells with little effect on normal cells. It is promising for cancer treatment, but some cancer cells appeared to be resistant to TRAIL-induced apoptosis. We showed that pretreatment with physiological doses of DHA results in significantly enhanced TRAIL-induced apoptosis of otherwise resistant human colon cells as documented by increased caspase activation and cleavage of their substrates. We demonstrated activation of crucial mitochondrial proapototic molecules, such as Bax and Bak. (en)
Title	Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways (en)
skos:prefLabel	Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways (en)
skos:notation	RIV/00216224:14310/11:00062482!RIV13-MSM-14310___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kozubík, Alois Hofmanová, Jiřina
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	195176
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00062482
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Docosahexaenoic acid colon cancer apoptosis sphingolipids (en)
http://linked.open.../riv/klicoveSlovo	Docosahexaenoic acid colon cancer apoptosis sphingolipids
http://linked.open...ontrolniKodProRIV	[861D4BC199AA]
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Kozubík, Alois Skender, Belma Vaculová, Alena Machala, Miroslav Slavík, Josef
http://bibframe.org/vocab/doi	10.1016/j.chemphyslip.2011.05.106
http://localhost/t...ganizacniJednotka	14310

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