About: In vitro modulation of intracellular receptor signaling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions.

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About: In vitro modulation of intracellular receptor signaling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The primary goal of this study was to determine if individual cyanobacterial species and mixtures of cyanobacteria collected from the environment contain compounds with the potential for interaction with signaling pathways of the aryl hydrocarbon receptor (AhR), androgen receptor (AR), estrogen receptor (ER), glucocorticoid receptor (GR) and retinoid acid receptor (RAR). Cytotoxicity and specific toxic potencies of products of freshwater cyanobacteria were determined by use of in vitro reporter gene trans-activation assays. Extracts of natural complex cyanobacterial biomasses exhibited greater and more frequent presence of compounds with specific modes of action, mainly estrogenic, and also greater cytotoxicity than extracts of single cyanobacterial species. The primary goal of this study was to determine if individual cyanobacterial species and mixtures of cyanobacteria collected from the environment contain compounds with the potential for interaction with signaling pathways of the aryl hydrocarbon receptor (AhR), androgen receptor (AR), estrogen receptor (ER), glucocorticoid receptor (GR) and retinoid acid receptor (RAR). Cytotoxicity and specific toxic potencies of products of freshwater cyanobacteria were determined by use of in vitro reporter gene trans-activation assays. Extracts of natural complex cyanobacterial biomasses exhibited greater and more frequent presence of compounds with specific modes of action, mainly estrogenic, and also greater cytotoxicity than extracts of single cyanobacterial species. (en)
Title	In vitro modulation of intracellular receptor signaling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions. In vitro modulation of intracellular receptor signaling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions. (en)
skos:prefLabel	In vitro modulation of intracellular receptor signaling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions. In vitro modulation of intracellular receptor signaling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions. (en)
skos:notation	RIV/00216224:14310/11:00050448!RIV12-GA0-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B08036), P(ED0001/01/01), P(GA524/08/0496), S, Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	3-4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Bláha, Luděk Hilscherová, Klára Štěpánková, Tereza
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	204045
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00050448
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyanobacteria; Cell extract; Endocrine disruption; Estrogenicity; Microcystin; Planktothrix agardhii (en)
http://linked.open.../riv/klicoveSlovo	Cell extract Endocrine disruption Estrogenicity Microcystin Planktothrix agardhii Cyanobacteria
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[97F34BDAF6B6]
http://linked.open...i/riv/nazevZdroje	Aquatic toxicology
http://linked.open...in/vavai/riv/obor	DJ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Tumor promotional mechanisms of cyanobacterial metabolites CETOCOEN New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Hilscherová, Klára Ambrožová, L. Giesy, J. P. Štěpánková, Tereza
http://linked.open...ain/vavai/riv/wos	000298120600033
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0166-445X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.aquatox.2011.08.002
http://localhost/t...ganizacniJednotka	14310

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