About: Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter

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About: Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In vitro effects of binary mixtures of various DOM (mainly HS) with various HOCs on AhR-mediated responses were studied by use of H4IIE-luc cells. 6 out of 12 DOM activated the AhR even at environmentally relevant concentrations (17 mg L(-1)). In simultaneous exposures of H4IIE-luc cells to DOM and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of POPs, a mixture of PAHs, and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs. No significant decrease of effects due to sorption of HOCs to DOM was observed, even in subsequent experiments when HOCs + DOM mixtures were preincubated for six days before exposure to H4IIE-luc. Thus, DOM does not seem to protect organisms against AhR-mediated toxic effects of HOCs (as predicted due to sorption of HOCs on DOM), but it can enhance their potency for AhR-mediated effects in some situations. In vitro effects of binary mixtures of various DOM (mainly HS) with various HOCs on AhR-mediated responses were studied by use of H4IIE-luc cells. 6 out of 12 DOM activated the AhR even at environmentally relevant concentrations (17 mg L(-1)). In simultaneous exposures of H4IIE-luc cells to DOM and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of POPs, a mixture of PAHs, and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs. No significant decrease of effects due to sorption of HOCs to DOM was observed, even in subsequent experiments when HOCs + DOM mixtures were preincubated for six days before exposure to H4IIE-luc. Thus, DOM does not seem to protect organisms against AhR-mediated toxic effects of HOCs (as predicted due to sorption of HOCs on DOM), but it can enhance their potency for AhR-mediated effects in some situations. (en)
Title	Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter (en)
skos:prefLabel	Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter (en)
skos:notation	RIV/00216224:14310/11:00050132!RIV12-GA0-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(ED0001/01/01), P(GP525/08/P464), S, Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Bittner, Michal Macíková, Petra Hilscherová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	197610
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00050132
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Humic substances; AhR; Mixture; Interaction; H4IIE-luc; Organic pollutants (en)
http://linked.open.../riv/klicoveSlovo	H4IIE-luc Humic substances Interaction Mixture Organic pollutants AhR
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9AD132936660]
http://linked.open...i/riv/nazevZdroje	Environment International
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction of humic substances and UV-VIS irradiation with dioxin-like environmental pollutants CETOCOEN
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	37
http://linked.open...iv/tvurceVysledku	Hilscherová, Klára Bittner, Michal Giesy, John P. Macíková, Petra
http://linked.open...ain/vavai/riv/wos	000292012100017
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0160-4120
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.envint.2011.03.016
http://localhost/t...ganizacniJednotka	14310

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