About: Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands

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About: Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lectins are proteins or glycoproteins of non-immune origin which recognize and bind reversibly to diverse sugar structures. They are involved in recognition events in a variety of physiological and pathological processes. One of the most interesting biological function of these sugar-specific proteins is their involvement in host-pathogen interactions. Wide range of pathogenic bacteria and viruses use their surface lectins (called adhesins) for recognition and adhesion to host tissues – in the the crucial step for initiation of infection. Inhibition of these lectins by suitable carbohydrates or their analogs might prevent attachment of pathogens to host cells and prevent the disease outbreak. Aspergillus fumigatus is an ubiquitous saprophytic mold and opportunistic pathogen responsible for severe infections in immuno-compromised individuals. The project is focused on a detailed characterization of L-fucose specific lectin AFL from A. fumigatus. Lectins are proteins or glycoproteins of non-immune origin which recognize and bind reversibly to diverse sugar structures. They are involved in recognition events in a variety of physiological and pathological processes. One of the most interesting biological function of these sugar-specific proteins is their involvement in host-pathogen interactions. Wide range of pathogenic bacteria and viruses use their surface lectins (called adhesins) for recognition and adhesion to host tissues – in the the crucial step for initiation of infection. Inhibition of these lectins by suitable carbohydrates or their analogs might prevent attachment of pathogens to host cells and prevent the disease outbreak. Aspergillus fumigatus is an ubiquitous saprophytic mold and opportunistic pathogen responsible for severe infections in immuno-compromised individuals. The project is focused on a detailed characterization of L-fucose specific lectin AFL from A. fumigatus. (en)
Title	Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands (en)
skos:prefLabel	Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands (en)
skos:notation	RIV/00216224:14310/11:00050064!RIV12-GA0-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA303/09/1168), S, Z(MSM0021622413)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pokorná, Marie Komárek, Jan Houser, Josef Kostlánová, Nikola Wimmerová, Michaela
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	187207
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00050064
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lectins; Aspergillus fumigatus (en)
http://linked.open.../riv/klicoveSlovo	Aspergillus fumigatus lectins
http://linked.open...ontrolniKodProRIV	[5B66AECC7983]
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Lectins from human pathogens - structure, function, engineering
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Houser, Josef Imberty, Anne Komárek, Jan Kostlánová, Nikola Pokorná, Marie Wimmerová, Michaela
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
http://localhost/t...ganizacniJednotka	14310

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