About: The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells

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About: The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	c-Myb is a transcription factor expressed in immature hematopoietic cells and in various types of tumor cells, such as colon and breast carcinoma cells. It is implicated in control of proliferation, differentiation and apoptosis. Its function during migration and invasion remains unclear. The aim of this study is to assess the role of c-Myb in control of invasivity of colon cancer cells. To determine the effect of c-Myb on migration and invasion of CT26cMyb cells, we used the xCELLigence System that monitors a cell migration and invasivity continuously in real time. We showed that enhanced expression of c-Myb increased migration and invasivity of colon carcinoma CT26 cells. In addition, the proinvasive factor Slug was found up-regulated in c-Myb overexpressing CT26cMyb cells, suggesting that Myb uses this protein to control invasivity of colon carcinoma cells. This study demonstrates that c-Myb has an important role in the regulation of migration and invasion of cancer cells. c-Myb is a transcription factor expressed in immature hematopoietic cells and in various types of tumor cells, such as colon and breast carcinoma cells. It is implicated in control of proliferation, differentiation and apoptosis. Its function during migration and invasion remains unclear. The aim of this study is to assess the role of c-Myb in control of invasivity of colon cancer cells. To determine the effect of c-Myb on migration and invasion of CT26cMyb cells, we used the xCELLigence System that monitors a cell migration and invasivity continuously in real time. We showed that enhanced expression of c-Myb increased migration and invasivity of colon carcinoma CT26 cells. In addition, the proinvasive factor Slug was found up-regulated in c-Myb overexpressing CT26cMyb cells, suggesting that Myb uses this protein to control invasivity of colon carcinoma cells. This study demonstrates that c-Myb has an important role in the regulation of migration and invasion of cancer cells. (en)
Title	The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells (en)
skos:prefLabel	The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells (en)
skos:notation	RIV/00216224:14310/11:00049766!RIV12-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1115), P(GD204/08/H054), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šmarda, Jan Pekarčíková, Lucie Knopfová, Lucia
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	227420
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00049766
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	c-Myb; migration; invasivity; colon carcinoma cells (en)
http://linked.open.../riv/klicoveSlovo	colon carcinoma cells invasivity c-Myb migration
http://linked.open...ontrolniKodProRIV	[713C5C17DE84]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	The Student Scientific Conference on Cancer Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of c-Myb and Cox-2 proteins in colon carcinogenesis Molecular mechanisms of the cell proliferation and differentiation
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Knopfová, Lucia Pekarčíková, Lucie Šmarda, Jan
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2011-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Neuveden
https://schema.org/isbn	978-80-210-5442-4
http://localhost/t...ganizacniJednotka	14310

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