About: The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis     Goto   Sponge   NotDistinct   Permalink

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  • Tumor cells have often impaired classical caspase-dependent apoptosis pathway and may be therefore more sensitive to agents that trigger alternative cell death pathways. Targeting lysosomes represents a method of choice as many human tumors have increased levels of lysosomal proteases. The lysosomal permeabilization pathway therefore offers a therapeutic window between cancer cells and normal tissue. TRAIL represents an anti-cancer therapeutic that can induce both classical and lysosomal apoptotic signaling. The lysosomal aspartic protease cathepsin D (cath-D) acts as mediator of induced-apoptosis by various chemotherapeutics. It has been suggested that cath-D can alter apoptosis pathways in enzymatic activity-dependent and independent manner. We conclude that Cath-D sensitizes breast carcinoma cells MDA-MB-231 to TRAIL-induced apoptosis in enzymatic activity-dependent manner.
  • Tumor cells have often impaired classical caspase-dependent apoptosis pathway and may be therefore more sensitive to agents that trigger alternative cell death pathways. Targeting lysosomes represents a method of choice as many human tumors have increased levels of lysosomal proteases. The lysosomal permeabilization pathway therefore offers a therapeutic window between cancer cells and normal tissue. TRAIL represents an anti-cancer therapeutic that can induce both classical and lysosomal apoptotic signaling. The lysosomal aspartic protease cathepsin D (cath-D) acts as mediator of induced-apoptosis by various chemotherapeutics. It has been suggested that cath-D can alter apoptosis pathways in enzymatic activity-dependent and independent manner. We conclude that Cath-D sensitizes breast carcinoma cells MDA-MB-231 to TRAIL-induced apoptosis in enzymatic activity-dependent manner. (en)
Title
  • The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis
  • The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis (en)
skos:prefLabel
  • The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis
  • The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis (en)
skos:notation
  • RIV/00216224:14310/11:00049429!RIV12-GA0-14310___
http://linked.open...avai/riv/aktivita
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  • P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
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  • 219225
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  • RIV/00216224:14310/11:00049429
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  • cathepsin D; apoptosis; breast cancer; TRAIL (en)
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  • [4EE973CF0C1E]
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  • Beneš, Petr
  • Jančeková, Blanka
  • Šmarda, Jan
  • Ondroušková, Eva
http://linked.open...n/vavai/riv/zamer
http://localhost/t...ganizacniJednotka
  • 14310
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