About: Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

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About: Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Introduction: Breast cancer is one of the most common types of cancer in women. One of the genes that were found mutated in breast cancer is casein kinase 1 epsilon (CK1 epsilon). Because CK1 epsilon is a crucial regulator of the Wnt signaling cascades, we determined how these CK1 epsilon mutations interfere with the Wnt pathway and affect the behavior of epithelial breast cancer cell lines. Results: In silico modeling and in vivo data showed that autophosphorylation at Thr 44, a site adjacent to the breast cancer point mutations in the N-terminal lobe of human CK1 epsilon, is involved in positive regulation of the CK1 epsilon activity. Introduction: Breast cancer is one of the most common types of cancer in women. One of the genes that were found mutated in breast cancer is casein kinase 1 epsilon (CK1 epsilon). Because CK1 epsilon is a crucial regulator of the Wnt signaling cascades, we determined how these CK1 epsilon mutations interfere with the Wnt pathway and affect the behavior of epithelial breast cancer cell lines. Results: In silico modeling and in vivo data showed that autophosphorylation at Thr 44, a site adjacent to the breast cancer point mutations in the N-terminal lobe of human CK1 epsilon, is involved in positive regulation of the CK1 epsilon activity. (en)
Title	Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration. Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration. (en)
skos:prefLabel	Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration. Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration. (en)
skos:notation	RIV/00216224:14310/10:00067265!RIV14-MSM-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA204/09/0498), P(GA301/07/0814), P(GD204/09/H058), S, Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50070508), Z(AV0Z60220518), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	12/3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Trantírek, Lukáš Bernatík, Ondřej Kozubík, Alois Bryja, Vítězslav Tmejová, Kateřina Krejčí, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	249211
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00067265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	KINASE-I-EPSILON; BETA-CATENIN; EPITHELIAL-CELLS; DISHEVELLED PHOSPHORYLATION; REGULATES GASTRULATION; SIGNALING PATHWAY; TUMOR PROGRESSION; UP-REGULATION; WNT PATHWAY; E-CADHERIN (en)
http://linked.open.../riv/klicoveSlovo	SIGNALING PATHWAY BETA-CATENIN EPITHELIAL-CELLS E-CADHERIN TUMOR PROGRESSION DISHEVELLED PHOSPHORYLATION KINASE-I-EPSILON REGULATES GASTRULATION UP-REGULATION WNT PATHWAY
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E3C9ED98FD46]
http://linked.open...i/riv/nazevZdroje	Breast Cancer Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Intercellular signalling in development and disease Role of Casein Kinase Iepsilon in breast cancer Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2010
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Kozubík, Alois Krejčí, Pavel Tmejová, Kateřina Dolezal, T. Trantírek, Lukáš Bernatík, Ondřej Brumovská, E. Blankenfeldt, W. Foldynová-Trantírková, S. Sekyrová, P.
http://linked.open...ain/vavai/riv/wos	000285689000006
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1465-5411
number of pages	2 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/bcr2581
http://localhost/t...ganizacniJednotka	14310

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