About: Off-line coupling of automated pipetting system with square wave voltammetry as a tool for study of drug-DNA interaction

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About: Off-line coupling of automated pipetting system with square wave voltammetry as a tool for study of drug-DNA interaction Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Manual handling with DNA and drugs can be a source of errors, which can be eliminated also by automation of whole process of sample preparation. The aim of this work was to study interaction between DNA and ellipticine by using of off-line coupled automated pipetting system with adsorptive transfer stripping technique (AdTS) square wave voltammetry (SWV). Interaction between dsDNA and ellipticine was evident from the decrease of CA signal. Six ng of ellipticine per ml resulted in a statistically significant decrease in CA signal (the decrease was higher than the standard deviation of determinations, Student t-test). The decrease in CA signal corresponded to increasing ellipticine concentrations. Manual handling with DNA and drugs can be a source of errors, which can be eliminated also by automation of whole process of sample preparation. The aim of this work was to study interaction between DNA and ellipticine by using of off-line coupled automated pipetting system with adsorptive transfer stripping technique (AdTS) square wave voltammetry (SWV). Interaction between dsDNA and ellipticine was evident from the decrease of CA signal. Six ng of ellipticine per ml resulted in a statistically significant decrease in CA signal (the decrease was higher than the standard deviation of determinations, Student t-test). The decrease in CA signal corresponded to increasing ellipticine concentrations. (en)
Title	Off-line coupling of automated pipetting system with square wave voltammetry as a tool for study of drug-DNA interaction Off-line coupling of automated pipetting system with square wave voltammetry as a tool for study of drug-DNA interaction (en)
skos:prefLabel	Off-line coupling of automated pipetting system with square wave voltammetry as a tool for study of drug-DNA interaction Off-line coupling of automated pipetting system with square wave voltammetry as a tool for study of drug-DNA interaction (en)
skos:notation	RIV/00216224:14310/10:00063547!RIV13-MSM-14310___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0505), P(GA102/08/1546), P(GAP301/10/0356), P(GD102/09/H083), P(KAN208130801), Z(MSM0021620808), Z(MSM0021622412), Z(MSM0021630513)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Trnková, Libuše
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	276524
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00063547
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ellipticine; DNA; square wave voltammetry; adsorptive transfer technique; automation (en)
http://linked.open.../riv/klicoveSlovo	ellipticine square wave voltammetry DNA automation adsorptive transfer technique
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[F4DB1FD94FD4]
http://linked.open...i/riv/nazevZdroje	Chimica Oggi/Chemistry today
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Information Technology in Biomedical Engineering Center of targeted therapeutic drugs Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Miniaturized intelligent systems and nanostructured elektrodes for chemical, biological, and pharmaceutical applications (NANIMEL)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Eckschlager, Tomáš Hubálek, Jaromír Kizek, René Stiborová, Marie Trnková, Libuše Huska, Dalibor Provaznik, Ivo
http://linked.open...ain/vavai/riv/wos	000283582200005
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Advanced Electronic Communication Systems and Technologies (ELCOM)
issn	1973-8250
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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