About: Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases.     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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Description
  • Inhibition of cyclin-dependent kinases (CDKs) has emerged as an attractive strategy for the development of novel oncol. therapeutics. Herein is described the utilization of an in vivo screening approach with integrated efficacy and tolerability parameters to identify candidate CDK inhibitors with a suitable balance of activity and tolerability. This approach has resulted in the identification of SCH 727965, a potent and selective CDK inhibitor that is currently undergoing clin. evaluation.
  • Inhibition of cyclin-dependent kinases (CDKs) has emerged as an attractive strategy for the development of novel oncol. therapeutics. Herein is described the utilization of an in vivo screening approach with integrated efficacy and tolerability parameters to identify candidate CDK inhibitors with a suitable balance of activity and tolerability. This approach has resulted in the identification of SCH 727965, a potent and selective CDK inhibitor that is currently undergoing clin. evaluation. (en)
Title
  • Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases.
  • Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases. (en)
skos:prefLabel
  • Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases.
  • Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases. (en)
skos:notation
  • RIV/00216224:14310/10:00045046!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 254586
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/10:00045046
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cdk; kinase; inhibitor; cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [ECA67655901B]
http://linked.open...i/riv/nazevZdroje
  • ACS Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2010
http://linked.open...iv/tvurceVysledku
  • Alvarez, Carmen
  • Dwyer, Michael
  • Fischmann, Thierry
  • Guzi, Timothy
  • Keertikar, Kerry
  • Madison, Vincent
  • Parry, David
  • Paruch, Kamil
  • Rossman, Randall
  • Seghezzi, Wolfgang
  • Shanahan, Frances
  • Brown, Courtney
  • Chan, Tin-Yau
  • Doll, Ronald
  • Hruza, Alan
  • James, Ray
  • Kirschmeier, Paul
  • Knutson, Chad
  • Lees, Emma
  • McKittrick, Brian
  • Nomeir, Amin
  • Paradkar, Vidyadhar
  • Park, Haengsoon
  • Rivera, Jocelyn
  • Rokosz, Laura
  • Schultz, Lesley
  • Sgambellone, Nicole
  • Stauffer, Tara
  • Tucker, Greg
  • Wang, Yaolin
  • Wiswell, derek
  • Xu, Xiaoying
  • Zhou, Quiao
issn
  • 1948-5875
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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