About: The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site on tubulin is examined on the basis of the interligand NOEs observed between epothilone A and tubulysin A in the presence of tubulin. Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site on tubulin is examined on the basis of the interligand NOEs observed between epothilone A and tubulysin A in the presence of tubulin. (en)
Title	The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin (en)
skos:prefLabel	The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin (en)
skos:notation	RIV/00216224:14310/10:00044991!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	28
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kubíček, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	293713
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00044991
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	conformation analysis; cytotoxicity; microtubules; NMR spectroscopy; tubulysin (en)
http://linked.open.../riv/klicoveSlovo	conformation analysis cytotoxicity NMR spectroscopy microtubules tubulysin
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[766811F9C2C6]
http://linked.open...i/riv/nazevZdroje	Angewandte Chemie International Edition
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Kubíček, Karel Carlomagno, Teresa Grimm, S. Kaspar Orts, Julien Sasse, Florenz
http://linked.open...ain/vavai/riv/wos	000279743200023
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1433-7851
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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