About: Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells

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About: Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This work presents a detailed characterization of substrate-assisted laser desorption inductively coupled plasma mass spectrometry (SALD ICP-MS), a new approach in the determination of trace elements in submicrolitre volumes. SALD ICP-MS allows quantitative analysis of metals in liquid samples with defined volumes deposited onto an absorbing substrate due to complete sample desorption at relatively low laser power density. Analysis of model samples of Cu(II) showed a constant signal over a wide range of laser power density, an independence of signal on desorption modes and a wide linear dynamic range. SALD ICP-MS with its limit of detection for copper below 26 fg in submicrolitre samples was successfully applied to investigate cytotoxic effects of disulfiram in human myeloid leukemia cells U937 depending on intracellular levels of copper. This work presents a detailed characterization of substrate-assisted laser desorption inductively coupled plasma mass spectrometry (SALD ICP-MS), a new approach in the determination of trace elements in submicrolitre volumes. SALD ICP-MS allows quantitative analysis of metals in liquid samples with defined volumes deposited onto an absorbing substrate due to complete sample desorption at relatively low laser power density. Analysis of model samples of Cu(II) showed a constant signal over a wide range of laser power density, an independence of signal on desorption modes and a wide linear dynamic range. SALD ICP-MS with its limit of detection for copper below 26 fg in submicrolitre samples was successfully applied to investigate cytotoxic effects of disulfiram in human myeloid leukemia cells U937 depending on intracellular levels of copper. (en)
Title	Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells (en)
skos:prefLabel	Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells (en)
skos:notation	RIV/00216224:14310/10:00043957!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1025), S, Z(MSM0021622411), Z(MSM0021622412), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vaculovič, Tomáš Preisler, Jan Navrátilová, Jarmila Kanický, Viktor Šmarda, Jan Foltynová, Pavla Peš, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	290976
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00043957
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ATOMIC-ABSORPTION-SPECTROMETRY; LA-ICP-MS; CAPILLARY-ELECTROPHORESIS; CALIBRATION STRATEGY; GEL-ELECTROPHORESIS; PROTEASOME ACTIVITY; BIOLOGICAL SAMPLES; TRACE-METALS; ABLATION; DISULFIRAM (en)
http://linked.open.../riv/klicoveSlovo	DISULFIRAM LA-ICP-MS CAPILLARY-ELECTROPHORESIS ATOMIC-ABSORPTION-SPECTROMETRY ABLATION BIOLOGICAL SAMPLES CALIBRATION STRATEGY GEL-ELECTROPHORESIS PROTEASOME ACTIVITY TRACE-METALS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9A24CAC08DE3]
http://linked.open...i/riv/nazevZdroje	JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Multidetection platform for microcolumn separation of proteins and peptides
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Kanický, Viktor Preisler, Jan Vaculovič, Tomáš Šmarda, Jan Foltynová, Pavla Peš, Ondřej Navrátilová, Jarmila
http://linked.open...n/vavai/riv/zamer	Study and application of plasma chemical reactions in non-isothermic low temperature plasma and its interaction with solid surface Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Molecular basis of cell and tissue regulations
issn	0267-9477
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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