About: Preparation of microsamples for elemental analysis of biological samples

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	New approaches of sample introduction to inductively-coupled plasma mass spectrometry which are especially suitable for minute amount of samples are presented. Detailed characterization of SALD ICP MS has shown large signal stability over a wide range of laser power density values, the independence of signal on acquisition modes and linear dynamic range over six orders of magnitude. SALD ICP MS with low limits of detection (0.1-14 fmol for Cr, Cu, Co, Fe, Ni, Sn and Zn) is suitable for off-line coupling with capillary electrophoresis (CE) for speciation analysis or selective detection of metals. Applicability to biological samples analysis was demonstrated on investigation of the role of copper ions to regulate cytotoxicity of disulfiram in myeloid leukemia cells. SALD ICP MS allows rapid, sensitive and reproducible method for quantitative analysis of metals with very low consumption of sample. New approaches of sample introduction to inductively-coupled plasma mass spectrometry which are especially suitable for minute amount of samples are presented. Detailed characterization of SALD ICP MS has shown large signal stability over a wide range of laser power density values, the independence of signal on acquisition modes and linear dynamic range over six orders of magnitude. SALD ICP MS with low limits of detection (0.1-14 fmol for Cr, Cu, Co, Fe, Ni, Sn and Zn) is suitable for off-line coupling with capillary electrophoresis (CE) for speciation analysis or selective detection of metals. Applicability to biological samples analysis was demonstrated on investigation of the role of copper ions to regulate cytotoxicity of disulfiram in myeloid leukemia cells. SALD ICP MS allows rapid, sensitive and reproducible method for quantitative analysis of metals with very low consumption of sample. (en)
Title	Preparation of microsamples for elemental analysis of biological samples Preparation of microsamples for elemental analysis of biological samples (en)
skos:prefLabel	Preparation of microsamples for elemental analysis of biological samples Preparation of microsamples for elemental analysis of biological samples (en)
skos:notation	RIV/00216224:14310/10:00043578!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1025), Z(MSM0021622411), Z(MSM0021622412), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vaculovič, Tomáš Preisler, Jan Navrátilová, Jarmila Kanický, Viktor Šmarda, Jan Foltynová, Pavla Peš, Ondřej
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	281371
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00043578
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	off-line coupling; ICP MS; SALD; mass spectrometry; proteins; biological samples (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry biological samples proteins ICP MS SALD off-line coupling
http://linked.open...ontrolniKodProRIV	[2D3689C9FF49]
http://linked.open...v/mistoKonaniAkce	Praha
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	25th International Symposium on MicroScale Bioseparations MSB 2010
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Multidetection platform for microcolumn separation of proteins and peptides
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Kanický, Viktor Preisler, Jan Vaculovič, Tomáš Šmarda, Jan Foltynová, Pavla Peš, Ondřej Navrátilová, Jarmila
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2010-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Study and application of plasma chemical reactions in non-isothermic low temperature plasma and its interaction with solid surface Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Molecular basis of cell and tissue regulations
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	IACh AS CR, v.v.i.
https://schema.org/isbn	978-80-254-6631-5
http://localhost/t...ganizacniJednotka	14310

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